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Updated: Jul 6, 2025

Fluorescence-based Neuraminidase Inhibition Assay to Assess the Susceptibility of Influenza Viruses to The Neuraminidase Inhibitor Class of Antivirals
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对具有临床相关性流感内核酶变异的抑制剂进行结构研究

Alysia J Kohlbrand1, Ryjul W Stokes1, Banumathi Sankaran2

  • 1Department of Chemistry and Biochemistry, University of California, La Jolla, California 92093, United States.

Biochemistry
|January 8, 2024
PubMed
概括

流感中的巴洛克萨维尔马博西尔 (BXM) 耐药性与PAN突变有关. 这项研究揭示了这些突变如何改变蛋白质抑制剂相互作用,为开发新的抗病毒药物提供了洞察力.

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Leaky Scanning02:28

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During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R...
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