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相关概念视频

Bone Disorders01:29

Bone Disorders

3.5K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.5K
Bone Remodeling01:40

Bone Remodeling

38.3K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.3K
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

2.9K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
2.9K
What is the Skeletal System?01:02

What is the Skeletal System?

52.7K
Overview
52.7K
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

2.7K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.7K
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

3.3K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.3K

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相关实验视频

Updated: Jul 6, 2025

Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice
07:20

Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice

Published on: August 23, 2024

536

骨质疏松症是一种骨质疏松症.

Kristine E Ensrud1, Carolyn J Crandall2

  • 1University of Minnesota, Minneapolis, Minnesota (K.E.E.).

Annals of internal medicine
|January 8, 2024
PubMed
概括

骨质疏松症查识别了需要骨折预防药物的患者. 优化药物治疗时间,选择和持续时间可以最大限度地提高效益,同时最大限度地降低药物风险.

科学领域:

  • 老年学是一门学科.
  • 整形外科 整形外科 整形外科
  • 药理学 药理学是指药理学的学科.

背景情况:

  • 骨质疏松症是一种普遍的骨疾病,其特点是骨脆弱.
  • 骨折风险增加是骨质疏松症的主要后果.
  • 有效的查策略对于识别有风险的个体至关重要.

研究的目的:

  • 强调基于证据的骨质疏松查的重要性.
  • 强调优化药物治疗以预防骨折.
  • 为了平衡治疗的好处与潜在的长期药物危害.

主要方法:

  • 对骨质疏松症的基于证据的查策略的审查.
  • 在骨质疏松症管理中影响药物治疗决策的因素分析.
  • 对骨质疏松症药物的风险益处概况的评估.

主要成果:

  • 查改善了可能从治疗中受益的患者的识别.
  • 战略性药物治疗的启动,选择和持续时间是最大限度地预防骨折的关键.
  • 谨慎管理可以最大限度地减少与长期药物使用相关的不良影响.

结论:

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  • 基于证据的查对于有针对性的骨质疏松症治疗至关重要.
  • 个性化药物治疗方法可以提高骨折预防的有效性.
  • 均衡治疗的好处和危害对于长期患者的治疗结果至关重要.