线粒体局部化在现场自组装重编程瘤 免疫和代谢微环境用于增强癌症治疗
Zhilong Wang1, Qian Wang1, Hongmei Cao1
1Key Laboratory of Radiopharmacokinetics for Innovative Drugs, Chinese Academy of Medical Sciences, Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300192, P. R. China.
Advanced materials (Deerfield Beach, Fla.)
|January 8, 2024
概括
研究人员开发了一种新的线粒体自我组装系统来重新编程瘤微环境 (TME). 这种方法增强了癌细胞的死亡,并将冷瘤转化为热瘤,提高了治疗效率.
科学领域:
- 生物医学工程 生物医学工程
- 癌症治疗 癌症治疗
- 纳米医学是一种纳米医学.
背景情况:
- 固体瘤中的瘤微环境 (TME) 通常会阻碍有效的癌症治疗.
- 调节TME的免疫和代谢方面对于改善治疗结果至关重要.
研究的目的:
- 设计一个线粒体局部化在现场自组装系统用于TME重塑.
- 为了增强癌细胞的免疫性和破坏代谢可塑性.
主要方法:
- 在实验室中构建了一个基于的药物递送系统,形成纳米细胞.
- 通过级联响应过程在线粒体上实现现场自组装成功能纳米纤维.
- 利用有机体特异性的自我组装来触发由线粒介导的细胞死亡.
主要成果:
- 该系统诱导了内等质网膜应激和非典型的II型免疫细胞死亡.
- 破坏了线粒体超结构,阻碍了瘤细胞的代谢可塑性.
- 成功地将免疫抑制的TME重塑为免疫刺激的TME.
- 抑制瘤转移并将"冷"瘤转化为"热"瘤.
结论:
- 线粒体自我组装系统有效地重塑TME并增强癌细胞死亡.
- 这种策略改善了瘤对放射治疗和免疫检查点阻塞疗法的敏感性.
- 提供了一种普遍的方法来控制子器官上的超分子自我组装,以决定癌细胞的命运并改善治疗.
相关概念视频
02:17The Tumor Microenvironment
6.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K
01:27Tumor Immunotherapy
527
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
527
01:46Electron Transport Chain: Complex I and II
13.4K
The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
ROS generation is regulated and maintained at moderate levels necessary...
13.4K
02:57Targeted Cancer Therapies
7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.6K
02:53Adaptive Mechanisms in Cancer Cells
5.8K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
5.8K