(-) - - 赛林加瑞诺醇通过改善肠道上皮质屏障功能和抑制炎症反应来减轻性结肠炎
Yunhe Liu1, Junzhe Wu1, Luying Tan1
1School of Pharmaceutical Sciences, Jilin University, Changchun, Jilin 130021, China.
概括
(-) - - 西林加瑞诺 (SYR) 通过加强肠道屏障和减少炎症,有效治疗性结肠炎 (UC). 这种天然的原体显示出作为UC治疗剂的潜力.
科学领域:
- 自然产品化学 自然产品化学
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
背景情况:
- (-) -Syringaresinol (SYR) 是一种具有已知的抗氧化和抗炎性质的灵,已经证明了各种药理上的益处.
- 虽然它在性结肠炎 (UC) 中的反抗体的疗效已经确立,但SYR在UC中的直接作用和机制仍然不清楚.
研究的目的:
- 调查SYR对UC的保护作用.
- 阐明SYR在UC中的作用的潜在分子机制.
主要方法:
- 对SYR对肠上皮质屏障功能和炎症反应的影响使用脂多糖 (LPS) 诱导的Caco-2细胞和硫酸 (DSS) 诱导的UC小鼠模型进行了评估.
- 转录组分析和西部斑点测试被用来探索SYR调节的信号通路.
主要成果:
- 在细胞和动物模型中,SYR治疗显著改善了肠道屏障完整性,减少了关键炎症标记物 (TNF-α,IL-6,IFN-γ,COX-2),并增强了紧结蛋白表达.
- 在DSS诱导的UC小鼠中,SYR的剂量取决于改善了临床结果,减少了炎症和细菌转移,并保留了结肠粘膜超结构.
- 转录组分析显示,SYR的抗UC作用通过PI3K-Akt/MAPK/Wnt信号通路进行介导.
结论:
- 通过加强肠上皮质屏障功能和抑制炎症反应,SYR有效地减轻UC的发展.
- 天然素SYR为治疗性结肠炎提供了一个有前途的治疗候选者.
关键词:
() - - 注液中的醇.炎症 炎症是一种炎症.肠道上皮质屏障 肠道上皮质屏障在PI3K-Akt/MAPK/Wnt信号通路中.文字转录学 (Transcriptomics) 是一个学科.性结肠炎是一种更多相关视频
09:11Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model
Published on: February 14, 2021
9.4K
06:31Author Spotlight: Studying the Epithelial Effects of Intestinal Inflammation In Vitro on Established Murine Colonoids
Published on: June 2, 2023
1.0K
相关概念视频
01:29Drugs for Treatment of Ulcerative Colitis in IBD
142
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
142
01:24Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents
490
In the intricate landscape of the gastric lumen, excessive acid secretion disrupts the natural defense mechanisms, weakening the mucus-bicarbonate barrier. This vulnerability allows pepsin to infiltrate epithelial cells, digesting mucosal proteins and triggering erosion, leading to ulcer formation.
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...
490
01:17Drugs for Treatment of Diarrhea-Predominant IBS
176
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
176
01:23Renewal of Intestinal Stem Cells
2.6K
The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
2.6K
01:21Inflammatory Bowel Disease V: Surgical Management
147
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Here are some common surgical interventions for IBD:
147
01:17Chronic Bowel Disorders: Introduction
455
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
455