一个研究定义和框架急性儿科重症跨资源变量设置:一个修改的Delphi共识
Anita V Arias1, Michael Lintner-Rivera2, Nadeem I Shafi3
1Division of Critical Care and Pulmonary Medicine, Department of Pediatrics, St Jude Children's Research Hospital, Memphis, TN, USA.
为统一全球研究,制定了急性儿科重症 (DEFCRIT) 的新定义. 该框架解决了儿童的生理不稳定或临床支持需求,无论当地资源如何.
科学领域:
- 全球健康 全球健康
- 儿科重症监护中心儿童重症监护中心
- 临床定义 临床定义
背景情况:
- 由于缺乏标准化定义,人们对急性儿科重症的全球负担的了解很少.
- 现有的定义往往取决于当地医疗保健能力,限制了全球研究的可比性.
研究的目的:
- 为急性儿科重症病 (DEFCRIT) 制定基于证据的,基于共识的定义和框架.
- 为了建立一个普遍的标准来识别和研究严重疾病的儿童在世界各地,无论资源设置.
主要方法:
- 对29项研究的范围审查确定了关键概念.
- 一个国际专家小组 (n=24) 改进了概念.
- 在经过修改的德尔菲过程中,有109名多学科专家在最终的定义和框架上达成共识.
主要成果:
- 在DEFCRIT的8个基本属性和28个声明上达成共识.
- 最终的定义包括生理不稳定或临床支持要求,以防止儿童的病情恶化或死亡.
- 在两轮Delphi中,专家的保留率达到了89%.
结论:
- 拟议的DEFCRIT为儿童重症病的统一全球研究方法提供了概念上的清晰度.
- 未来的研究将专注于验证DEFCRIT,并制定其在各种环境中的实施指南.
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