与双相情绪障碍中客观和主观认知障碍之间的差异相关的因素
C M Bonnín1, J Sánchez-Moreno2, F Lima3
1Bipolar and Depressive Disorders Unit, Hospìtal Clinic de Barcelona, c. Villarroel, 170, 08036 Barcelona, Spain; Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain; Psychiatry Department, Institut d'Investigació Biomèdica-Sant Pau (IIBSANT PAU), Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Catalonia, Spain.
Journal of affective disorders
|January 8, 2024
概括
患有双相情感障碍 (BD) 的患者可能在抑郁症后过度报告认知问题,但在住院后报告不足. 了解这些差异是准确认知评估和BD治疗的关键.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知心理学 认知心理学
背景情况:
- 双极性障碍 (BD) 通常与认知障碍有关.
- 客观认知功能和主观患者抱怨之间可能存在重大差异.
- 准确评估认知功能对于有效治疗BD至关重要.
研究的目的:
- 评估对象认知测量和主观认知投诉之间的差异,双相情感障碍 (BD) 的euthymic患者.
- 确定影响BD客观和主观认知评估之间的关系的因素.
主要方法:
- 评估了116名参与者 (83名BD患者,33名健康对照).
- 为了客观认知评估,使用了全面的神经心理学电池.
- 用双极性障碍认知投诉评级表 (COBRA) 衡量主观认知投诉.
- 用一种新的方法来计算客观和主观数据之间的差异.
- 统计分析包括皮尔森相关性和多重线性回归.
主要成果:
- 更多的先前抑郁症发作与过度报告认知投诉相关.
- 具体来说,更多的抑郁情节与全球敏感性 (Beta = 0.25,p = 0.04) 和口头学习/记忆敏感性 (Beta = 0.26,p = 0.03) 有关.
- 相反,以前住院次数较多与认知投诉 (stoicism) 的报告不足有关.
- 更多的住院治疗与全球分数 (Beta = -0.27,p = 0.029) 和注意力/处理速度 (Beta = -0.34,p = 0.016) 相相关.
结论:
- 以前的抑郁症发作和住院病例的数量是解释 BD 中客观和主观认知测量之间的差异的重要因素.
- 这些发现强调了利用客观和主观认知评估的必要性,以全面评估双相情感障碍的认知功能障碍.
- 综合评估方法对于量身定制有效的治疗策略至关重要 认知缺陷在BD.
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