从分子到生态系统:洞察查加斯病爆发的相互作用网络,使用Triatoma brasiliensis作为自然样本
Carlos E Almeida1, Milena M Máximo2, Dayane Pires-Silva3
1Universidade Federal da Paraíba (UFPB), Campus IV, Rio Tinto, Brasil; Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brasil.
Acta tropica
|January 8, 2024
概括
这项研究揭示了食物来源如何影响Triatoma brasiliensis载体中的查加斯病 (CD) 寄生虫负载. 人类因素推动了野生和家用环境之间的寄生虫循环,强调了社区对载体繁殖地点的认识的必要性.
科学领域:
- 生态流行病学 生态流行病学
- 疾病传播的动态.
- 载体传播疾病 载体传播疾病
背景情况:
- 查加斯病 (CD) 的传播涉及病原体,载体,宿主,人类和环境之间的复杂相互作用.
- 了解这些生态流行病学动态对于疾病控制至关重要.
- 人类影响极大地影响了疾病传播模式.
研究的目的:
- 在查加斯病中分析载体-寄生虫-宿主-环境相互作用.
- 为了研究食物来源多样性的影响Trypanosoma cruzi寄生虫负载在Triatoma brasiliensis.
- 评估人为因素在T. cruzi.循环中的作用.
主要方法:
- 对98名感染Triatoma brasiliensis的数量和质量分析.来自巴西的CD爆发.
- 无脊椎动物衍生的DNA (iDNA) 提取和线粒体基因测序 (cyt b) 用于食物来源的识别.
- 光放大片段条形码 (FFLB) 用于寄生虫基因类型和实时PCR用于寄生虫负载量化.
主要成果:
- 昆虫中的寄生虫负载受到食物来源多样性的显著影响.
- 与Kerodon rupestris相比,以Didelphis albiventris和Galea spixii为食的昆虫表现出较高的寄生虫负载.
- Galea spixii可能正在经历同人性化过程,而家猫表现出改变的行为,促进了T. cruzi的循环.
结论:
- 被忽视的人类活动促进了T. cruzi (TcI占主导地位) 在野外环境和周围环境之间的相互循环.
- 居民对载体繁殖地点缺乏认识,加剧了这个问题.
- 载体可以作为自然样本,以了解疾病传播的组成部分.
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