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特雷和德克斯之间的相互作用作为化脂质体的喷雾干燥前体

Anitta Lutta¹, Matthias M Knopp², Matteo Tollemeto³

¹Technical University of Denmark, Department of Health Technology, Ørsteds Plads 345C, 2800 Kgs. Lyngby, Denmark; Statens Serum Institut, Department of Infectious Disease and Immunology, Artillerivej 5, 2300 Copenhagen, Denmark.

International journal of pharmaceutics

|January 8, 2024

概括

喷雾干燥脂质体与三糖-德克斯混合物增强了口服输送. 这种配方可以保护脂质体并改善它们的补水,增加脂质度以改善药物输送.

科学领域:

制药技术制药技术制药技术
药物输送系统药物输送系统
生物材料科学生物材料科学

背景情况:

口服输送脂质体面临由于严重的胃肠道疾病的挑战.
固态配方和胃耐药装置对于成功的脂质体输送至关重要.
喷雾干燥是创建稳定,固态脂质体配方的关键技术.

研究的目的:

评估三醇-德克斯混合物作为喷雾干燥脂质体的脱水前体.
为了确定这些辅助剂在干燥过程中的保护能力.
为了优化最终干燥配方中的脂质体度和再化动力学.

主要方法:

使用各种三醇-德克斯混合物喷雾干燥CAF®04脂质体.
对脂质体保护和由此产生的干粉中的含量进行分析.
对优化配方的补水动力学的评估.
在喷雾干燥的脂质体中量化脂质度.

主要成果:

8.5%的德克斯和76.5%的三醇混合物在喷雾干燥过程中有效地保护了CAF®04脂质体.
脂质体含量保持在干粉配方的15%.
重水化动力学在高达8.5%的德克斯时略有改善.
脂质度增加了2.4倍 (从3mM增加到7.245mM).

结论:

醇是喷雾干燥CAF®04脂质体的重要载体.
加入少量德克斯可以调节喷雾干燥脂质体的补水特性.
这种方法增强了脂质体稳定性和脂质度,改善了口服输送潜力.

关键词:

德克斯兰 (Dextran) 是一种脂质体是一种脂质体.重水化动力学重水化动力学固体溶解度固体溶解度固体溶解度喷雾干燥喷雾干燥这种树脂含有三糖.

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