打印一种疗法:一种定制解决方案,用于在肝癌治疗中局部药物输送
Souha H Youssef1, Raja Ganesan2, Marzieh Amirmostofian3
1Centre for Pharmaceutical Innovation (CPI), University of South Australia, Adelaide, SA, Australia.
International journal of pharmaceutics
|January 8, 2024
概括
装有5-甲 (5FU) 和西斯 (Cis) 的可生物降解3D打印薄膜对肝癌辅助化疗有希望. 这些局部药物释放的植入物有效地降低了癌细胞的活力,并诱导了亡.
科学领域:
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
- 在瘤学瘤学.
背景情况:
- 辅助化疗对于预防肝癌复发至关重要.
- 系统化疗面临着局限性,导致需要局部替代方案.
- 药物释放植入物为化疗提供了针对性治疗方法.
研究的目的:
- 开发和描述可生物降解的3D打印双层薄膜,用于局部输送5-甲 (5FU) 和西斯 (Cis).
- 评估这些药物载膜对肝癌细胞的体外细胞毒性和诱导亡的作用.
主要方法:
- 可生物降解的双层薄膜使用3D打印制造,用于5FU和Cis.不同的填充百分比.
- 电影的特点是药物含量,药物释放动力学,稳定性和机械性能.
- 用MTS测定对HepG2肝癌细胞系进行细胞毒性评估.
- 通过Western Blots和线粒体潜能测定证实了亡.
主要成果:
- 3D打印的片成功封装了5FU和Cis,其中含有特定的药物.
- 根据片的设计,西斯的释放时间从12天到23天不等,而5FU则在24小时内释放.
- 薄膜在各种储存条件下表现出良好的稳定性.
- 观察到HepG2细胞活力的显著降低 (高达81%) 和确认的亡.
结论:
- 可生物降解的3D打印双层膜为肝癌的辅助化疗提供了一个有前途的局部药物递送系统.
- 开发的膜有效地提供5FU和Cis,诱导细胞毒性,并促进肝癌细胞的亡.
- 这种方法有可能改善治疗结果,克服全身化疗的局限性.
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