关于癌症患者血栓形成风险的更新:专注于新型抗癌免疫疗法
Florian Moik1,2, Jakob M Riedl2, Cornelia Englisch1
1Division of Haematology and Haemostaseology, Department of Medicine I, Medical University of Vienna, Vienna, Austria.
Hamostaseologie
|January 8, 2024
概括
新型癌症免疫疗法,如免疫检查点抑制剂 (ICI),CAR T细胞和BiTEs,增加了癌症患者的生存率,但也增加了血栓栓塞事件 (VTE/ATE) 的风险. 了解这些风险对于制定心血管预防策略至关重要.
科学领域:
- 在瘤学瘤学.
- 心血管医学 心血管医学
- 免疫治疗是一种免疫疗法.
背景情况:
- 血栓栓塞栓并发症 (VTE/ATE) 在癌症患者中显著增加死亡率和发病率.
- 癌症治疗的进步,包括免疫疗法,延长了生存时间,但延长了血栓栓塞事件的风险期.
- 新出现的证据表明,新型抗癌免疫疗法可能具有直接的心血管毒性和前血栓性作用.
研究的目的:
- 审查新型抗癌免疫疗法对癌症患者血栓栓塞事件的影响.
- 总结有关与免疫检查点抑制剂 (ICI),CAR T细胞疗法和双特异性T细胞参与剂 (BiTEs) 相关的VTE和ATE率的当前数据.
- 在接受这些新型治疗的患者中确定血栓栓塞事件的风险因素和预测生物标志物.
主要方法:
- 现有文献的叙述性审查.
- 对ICI,CAR T细胞疗法和BTE治疗的患者中报告的VTE和ATE率的分析.
- 检查免疫治疗与血栓栓塞的潜在机制.
主要成果:
- 新型免疫疗法增加的存活率导致长时间暴露于血栓栓塞风险.
- ICI治疗与VTE和ATE的相关风险有关.
- 卡尔T细胞治疗和BiTE可能会导致静血失调,特别是在细胞因子释放综合征期间.
结论:
- 新型抗癌免疫疗法在癌症患者的血栓栓塞风险管理方面存在独特的挑战.
- 需要进一步的研究来阐明精确的机制,并制定有针对性的心血管预防策略.
- 对于接受免疫治疗的患者来说,密切监测血栓栓塞事件至关重要.
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