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抗血小板药物的先前使用对COVID-19易感性,进展和严重性的影响:基于人口的研究
Ángela Prieto-Campo1, Maruxa Zapata-Cachafeiro2, Manuel Portela-Romero3
1Departamento de Salud Pública, Facultad de Farmacia, Universidad de Santiago de Compostela, Santiago de Compostela, A Coruña, Spain.
使用triflusal可能会增加COVID-19感染风险和住院治疗,而阿司匹林可能会降低易感性. 这表明,在COVID-19大流行期间,应该重新考虑三种药物的处方.
科学领域:
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 感染导致高凝血和血栓栓塞,导致COVID-19的发病率和死亡率.
- 抗血小板药物是常用的,但它们对COVID-19结果的影响需要进一步调查.
研究的目的:
- 评估抗血小板药物对COVID-19严重程度的影响,包括住院和死亡风险.
- 评估抗血小板剂对SARS-CoV-2感染和疾病进展的敏感性的影响.
主要方法:
- 2020年在西班牙进行了一项基于人口的病例控制研究.
- 这项研究包括3060名住院COVID-19患者,26,757名非住院COVID-19患者,56,785名健康对照.
主要成果:
- 使用triflusal与住院风险 (aOR,1.97) 和感染易感性 (OR,1.45) 的显著增加有关.
- 阿司匹林使用与对SARS-CoV-2感染易感性的统计显著下降有关 (OR,0.92).
- 特里弗卢萨尔显示,死亡率和疾病进展风险的增加不显著.
结论:
- 处方Triflusal可能会增加COVID-19感染和住院的风险.
- 其他抗血小板药物,如阿司匹林,可能会降低感染风险或没有显著影响.
- 研究结果表明,需要在COVID-19大流行期间重新考虑使用triflusal.
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