纳林因和石墨烯氧化物结合Moringa oleifera/聚乙烯) 酒精补丁用于增强伤口愈合
S Baishal1, J Prakash2, M S Marvaan1
1Department of Nanotechnology, SRM Institute of Science and Technology, Kattankulathur, Tamil Nadu, India.
International journal of biological macromolecules
|January 8, 2024
概括
一个新型的聚合物贴片,结合了聚乙醇 (PVA),Moringa oleifera (MO),石墨烯氧化物 (GO) 和naringin (Nar),证明了加速伤口愈合. 这种PVA/MO/GO/Nar补丁在体外和体内研究中都显示出显著的改善.
科学领域:
- 生物材料科学 生物材料科学
- 再生医学是一种再生医学.
- 聚合物化学 聚合物化学
背景情况:
- 加快伤口愈合对于患者的康复和医疗保健效率至关重要.
- 聚合物材料为开发先进的伤口带提供了一个多功能平台.
- 纳入生物活性剂和纳米材料可以增强伤口补丁的治疗特性.
研究的目的:
- 制造和评估一种新型的聚合物贴片,该贴片含有聚乙烯醇 (PVA),Moringa oleifera (MO),石墨烯氧化物 (GO) 和naringin (Nar),用于伤口愈合.
- 调查开发的PVA/MO/GO/Nar贴片的体外和体内疗效.
- 为了描述合成的石墨烯氧化物和制造的聚合物补丁.
主要方法:
- 通过修改的汉默的方法和表征 (XRD,FT-IR,RAMAN,FESEM,HRTEM) 合成石墨烯氧化物 (GO).
- 制造PVA/MO/GO/窄聚合物贴片和评估物理特性 (形态,胀,降解,多孔性,WVTR).
- 试验室评估包括抗菌活性,生物相容性 (血液溶解试验),药物释放,划痕试验和MTT试验.
- 在白色Wistar老鼠的体内伤口愈合实验中.
主要成果:
- 合成的GO表现出了通过各种光谱和显微镜技术证实的特征性质.
- PVA/MO/GO/Nar补丁显示出对测试细菌具有显著的抗菌活性,并且具有良好的生物相容性.
- 实验室试验表明了有利于伤口愈合的特征,包括受控的药物释放和增强的细胞增殖.
- 在白色Wistar大鼠的体内研究表明,PVA/MO/GO/Nar贴片显著加快了伤口愈合.
结论:
- 开发的PVA/MO/GO/Nar聚合物贴片是先进的伤口愈合应用的有希望的候选者.
- 在单个贴片中PVA,MO,GO和Nar的组合协同增强了伤口愈合特性.
- 需要进一步的研究来探索这种新型伤口带的临床应用和长期疗效.
更多相关视频
相关概念视频
01:28Phases of Wound Repair
Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
01:24Drugs for Peptic Ulcer Disease: Sucralfate as Mucosal Protective Agents
In the intricate landscape of the gastric lumen, excessive acid secretion disrupts the natural defense mechanisms, weakening the mucus-bicarbonate barrier. This vulnerability allows pepsin to infiltrate epithelial cells, digesting mucosal proteins and triggering erosion, leading to ulcer formation.
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...
In this scenario, mucosal protective agents like sucralfate play an essential role. Sucralfate, a complex of sulfated sucrose and aluminum hydroxide, demonstrates its usefulness in acidic conditions,...