血清丸激素水平的影响反映与年龄相关的多器官功能
Tomoya Shirakawa1, Julius Fink1, Zen-U Hotta1
1Department of Urology, Juntendo University, Graduate School of Medicine, Tokyo 113-8421, Japan.
Endocrine journal
|January 8, 2024
概括
这项研究发现血清总和老年男性的各种生物标志物之间存在显著的相关性. 低丸激素可能与老年人多种器官功能障碍有关.
科学领域:
- 内分泌学 在内分泌学.
- 老年学是一门学科.
- 生物化学 生物化学
背景情况:
- 在男性中,血清总水平随着年龄的增长而下降.
- 与年龄相关的疾病通常与荷尔蒙失衡有关.
- 丸激素在维持生理恒温中起着至关重要的作用.
研究的目的:
- 为了研究血清总和多个器官功能的生物标志物在男性的大队伍之间的关联.
- 探索丸激素,衰老和与年龄有关的疾病生物标志物之间的关系.
- 为了确定丸激素水平是否与老年男性器官健康指标相关.
主要方法:
- 一项涉及12,547名男性门诊患者的横截面研究.
- 测量血清总水平的测量.
- 多重回归分析以评估和生物标志物之间的相关性:血红蛋白,血红素,LH,FSH,ALP,ALB,Cre,AST,ALT,Glu,CRP,TG,HDL-C和LDL-C.
主要成果:
- 在总和Hb,Hct,LH,FSH,ALP,ALB,TG,HDL-C,AST,ALT,Glu和CRP之间观察到显著的相关性 (p <0.05).
- 对于Hb,Hct,LH,FSH,ALP,ALB,TG和HDL-C与相互作用术语[年龄 × ]也发现了显著的相关性 (p < 0.05).
结论:
- 血清总丸激素与反映老年男性器官功能的多种生物标志物有显著的相关性.
- 这些发现表明,丸激素对于维持老年男性的平衡至关重要.
- 老年男性的阴性腺症可能与多个器官的功能障碍有关.
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