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使用CRISPR在非模型多细胞生物Bombyx mori中进行高通量和基因组规模的向突变发生

Sanyuan Ma1, Tong Zhang2, Ruolin Wang2

  • 1Integrative Science Center of Germplasm Creation in Western China (CHONGQING) Science City, Biological Science Research Center, Southwest University, Chongqing 400716, China; masy@swu.edu.cn xiaqy@swu.edu.cn.

Genome research
|January 8, 2024
PubMed
概括

研究人员在丝虫Bombyx mori.中创建了第一个大规模的CRISPR-Cas9突变库. 这一资源有助于理解基因功能和识别基因,以改善丝养殖中的经济特征.

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In-vitro Mutagenesis01:16

In-vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
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