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估计抗抑郁药的最小值得的差异:一个横截面调查
Ethan Sahker1,2, Toshi A Furukawa3, Yan Luo1,2
1Department of Health Promotion and Human Behavior, Graduate School of Medicine / School of Public Health, Kyoto University, Kyoto, Japan.
BMJ mental health
|January 8, 2024
概括
患者需要抗抑郁药来显示比没有治疗的20-25%更高的反应率,才能被认为是值得的. 目前的抗抑郁药只能提供15%的益处,这使得三分之二的患者想要更有效的选择.
科学领域:
- 精神病学和心理健康 精神病学和心理健康
- 临床药理学 临床药理学
- 患者报告的结果
背景情况:
- 抗抑郁药治疗的响应率为45%,而没有治疗的响应率为30%.
- 抗抑郁药的最小值得区别 (SWD) 定义不清楚.
- SWD量化了考虑到治疗负担的患者感知到的最低利益.
研究的目的:
- 为了估计抗抑郁药的SWD与抑郁症没有治疗相比.
- 为了帮助开发更有效的抗抑郁药疗法.
主要方法:
- 英国和美国的在线横截面调查 (N=935) (2022年10月至2023年1月).
- 参与者包括那些没有接受治疗的中度至重度抑郁症患者.
- 估计SWD为2个月后患者所需的响应率差异.
主要成果:
- 中位数SWD是中度至重度抑郁症患者的应答率20%的差异.
- 对于整个样本,SWD中位数是响应率的25%差异.
- 目前的抗抑郁药比不治疗提供了15%的益处.
结论:
- 三分之二的患者期望比目前的抗抑郁药提供更大的益处.
- 目前的抗抑郁药对许多患者来说是不够的.
- 需要更有效和/或更轻松的抗抑郁药,优先考虑患者的观点.
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