感染SARS-CoV-2的风险因素:一个测试负的病例控制研究,在挪威进行了额外的人口控制
Marjut Sarjomaa1,2, Chi Zhang3,4, Yngvar Tveten5
1Infection Control, Telemark Hospital, Skien, Norway sarm@sthf.no.
BMJ open
|January 8, 2024
概括
这项研究使用组合测试-阴性设计和人口控制来确定SARS-CoV-2感染的风险因素. 在这两项分析中,吸烟是COVID-19的一个显著的负面风险因素.
科学领域:
- 流行病学 流行病学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 了解SARS-CoV-2感染的风险因素对于公共卫生干预至关重要.
- 之前的研究使用了各种设计,但结合方法提供了更全面的观点.
研究的目的:
- 为了评估SARS-CoV-2感染的风险因素,使用组合测试负面设计 (TND) 和人口对照.
- 用不同的研究设计来比较PCR阳性病例和对照之间的风险因素关联.
主要方法:
- 一个多中心病例控制研究,测试设计呈阴性,并在挪威东南部进行额外的人口控制.
- 包括2020年2月至12月期间通过PCR测试SARS-CoV-2的成年人.
- 用自我报告的问卷数据来评估风险因素.
主要成果:
- 在TND中,男性性别与SARS-CoV-2风险有关,但与人口对照无关.
- 在这两项分析中,吸烟与SARS-CoV-2感染有负面关联.
- 诸如喘,木材加热和高血压等因素显示出不同的关联,取决于使用的对照组.
结论:
- 将TND与人口控制相结合,为识别SARS-CoV-2风险因素提供了一种可靠的方法.
- 吸烟是COVID-19的一个持续的负面风险因素.
- 对照组的选择对确定某些风险因素有很大影响.
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