在美国婴儿中使用20肺炎球菌合疫苗的成本效益
Mark H Rozenbaum1, Liping Huang2, Johnna Perdrizet3
1Pfizer, Capelle a/d Ijssel, Netherlands.
Vaccine
|January 8, 2024
概括
新型肺炎球菌合疫苗20-valent (PCV20) 与PCV13和PCV15.15相比,提供了显著的健康和经济效益. 预计PCV20的婴儿疫苗接种可以避免许多疾病病例和死亡,从而节省数十亿.
科学领域:
- 公共卫生 公共卫生
- 疫苗学 疫苗学 疫苗学
- 卫生经济学 卫生经济学
背景情况:
- 目前的美国婴儿疫苗接种计划包括15-valent (PCV15) 和20-valent (PCV20) 肺炎球菌联合疫苗.
- 本研究评估了使用PCV20配方用于婴儿免疫的健康和经济影响.
研究的目的:
- 与现有的疫苗推相比,评估PCV20婴儿疫苗接种对健康和经济的影响.
- 在十年内从社会和医疗保健系统的角度分析PCV20的成本效益.
主要方法:
- 使用基于人口的多队列马尔科夫模型来模拟健康和经济结果.
- 流行病学数据来源于已发表的文献和活性细菌核监测系统 (ABCs).
- 疫苗有效性估计来自PCV13有效性和PCV7有效性研究,并从观察数据分析间接影响.
主要成果:
- 据估计,PCV20疫苗接种可以预防超过55,000例侵入性肺炎球菌病 (IPD),250万例肺炎病例和540万例中耳炎 (OM) 病例.
- 这一战略预计可以避免19,000人死亡,在10年内获得515,000个生命年和271,000个QALY.
- 与PCV13相比,PCV20表现出了成本效益,导致净节省206亿美元,与PCV15相比,净节省99亿美元,并观察到显著的间接收益.
结论:
- 用PCV20接种婴儿疫苗是主要的策略,在健康益处和成本节省方面,其表现优于PCV13和PCV15.
- PCV20显著降低了肺炎球菌疾病负担以及相关的医疗保健和社会成本.
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