从回归模型中重新表达系数,用于纳入元分析
Matthew W Linakis1, Cynthia Van Landingham2, Alessandro Gasparini3
1Ramboll U.S. Consulting, Raleigh, NC, 27612, USA, 3214 Charles B Root Wynd #130. mlinakis@ramboll.com.
BMC medical research methodology
|January 8, 2024
概括
当数据转换不同时,合成元分析结果是很困难的. 对于回归系数的再表达方法往往会引入偏差,特别是偏斜的独立变量,使证据合成复杂化.
科学领域:
- 生物统计学 生物统计学
- 流行病学 流行病学
- 健康研究方法 健康研究方法
背景情况:
- 分析需要在各个研究中呈现一致的数据.
- 不统一的变量转换 (例如,日志与没有转换) 阻碍了结果合成.
- 最近的方法旨在重新表达回归系数以实现可比性.
研究的目的:
- 为了评估三种回归系数再表达方法的偏差.
- 评估独立变量偏差对再表达偏差的影响.
- 将重新表达的系数与未转换模型中的系数进行比较.
主要方法:
- 使用模拟和15个现实数据示例.
- 独立变量表现出偏斜的分布.
- 来自日志转换变量的回归系数被重新表达为未转换的尺度.
主要成果:
- 这三种再表达方法通常都产生了偏差的结果.
- 偏差的程度是由独立变量的斜率预测的.
- 重新表达的系数往往不同于从未被转换的数据中得出的系数.
结论:
- 对于回归系数的当前再表达方法通常具有偏差.
- 可变偏差是影响元分析偏差的一个关键因素.
- 从转换和未转换的数据中合成证据仍然具有挑战性和上下文依赖.
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