绝经后患有艾滋病毒的女性牙损失增加
Sunil Wadhwa1, Taylor R Finn2, Karolina Kister2
1Division of Orthodontics, Columbia University College of Dental Medicine, New York, NY, USA. sw2680@cumc.columbia.edu.
BMC oral health
|January 8, 2024
概括
绝经后患有艾滋病毒的女性经历了膜骨的恶化,导致牙的潜在损失. 这项研究突出了骨微型架构的显著差异和艾滋病毒感染妇女的RANKL表达的增加.
科学领域:
- 口腔健康研究 口腔健康研究
- 骨生物学 骨生物学
- 艾滋病毒/艾滋病研究研究
背景情况:
- 艾滋病毒感染者 (PWH) 正在衰老,大多数美国PWH都超过50岁.
- 更年期加速了PWH的骨损失.
- 气膜骨,来自神经,不同于长骨.
研究的目的:
- 评估艾滋病毒感染的绝经后妇女的牙周病.
- 评估艾滋病毒感染的绝经后妇女的膜骨微型架构.
主要方法:
- 招募了135名绝经后妇女 (59名艾滋病毒感染者,76名艾滋病毒感染者+).
- 测量了细胞因子水平,牙周参数,牙数量和膜骨微观结构.
- 分析了RANKL和其他细胞因子的牙裂液.
主要成果:
- 艾滋病毒感染女性的RANKL表达更高,牙更少.
- 艾滋病毒+妇女具有较差的膜骨微架构 (较低的状骨数,较大的分离).
- 在探测或附着损失时出血没有显著差异.
结论:
- 绝经后患有艾滋病毒的女性表现出膜骨微型架构的恶化.
- 这种恶化可能会增加牙损失的风险在这个人群.
相关概念视频
Teeth
431
The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
431
Pulmonary Tuberculosis I
243
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
243
Sexually Transmitted Infections
315
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
315
Bone Disorders
3.5K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.5K
Menopause
166
Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...
166
Retrovirus Life Cycles
46.0K
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
46.0K


