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Updated: Jul 6, 2025

CRISPR-Mediated Reorganization of Chromatin Loop Structure
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Published on: September 14, 2018

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PSIP1/LEDGF减少了转录部位的R循环,以保持基因组完整性

Sundarraj Jayakumar1,2, Manthan Patel1, Fanny Boulet1

  • 1Blizard Institute; Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK.

Nature communications
|January 8, 2024
PubMed
概括

蛋白质PSIP1通过管理转录部位的R循环来防止基因组损伤. PSIP1的枯竭会导致R循环积累,DNA损伤和改变的DNA修复,增加癌细胞对某些治疗方法的敏感性.

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