尿癌的全身抗癌疗法:英国瘤学家的观点
Robert J Jones1, Simon J Crabb2, Mark Linch3
1University of Glasgow, Beatson West of Scotland Cancer Centre, Glasgow, UK.
British journal of cancer
|January 8, 2024
概括
尿路细胞癌 (UC) 的全身治疗方法已经进步,以化疗作为标准. 本综述详细介绍了英国目前晚期UC的治疗途径,包括化疗和免疫疗法选择.
科学领域:
- 在瘤学瘤学.
- 尿癌研究 尿癌研究
背景情况:
- 尿癌 (UC) 在晚期呈现出不良预后.
- 基于的化疗是一种长期有效的UC治疗方法.
- 最近的进展改善了UC管理的结果.
研究的目的:
- 审查尿癌 (UC) 的全身治疗选择.
- 提供英国对UC当前护理标准的具体解释.
- 突出支持高级UC治疗途径的临床数据.
主要方法:
- 在UC中对全身抗癌治疗的临床数据的审查.
- 从英国的角度分析治疗途径.
- 包括作者对当前护理标准的解释.
主要成果:
- 建议在肌肉侵袭性膀癌中使用新辅助性思普拉丁化疗.
- 一线高级UC治疗包括白金化疗,然后是阿维卢马布维护.
- 免疫检查点抑制剂 (ICI) 是具有PD-L1阳性瘤的白金不合格患者的选择.
结论:
- 针对UC的全身疗法已经发展,提供了更好的结果.
- 治疗顺序是至关重要的,有选择,如恩福图马布维多丁 (enfortumab vedotin) 以后的线.
- 需要进一步研究的领域包括最佳化疗周期和PD-L1测试值.
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