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Updated: Jul 6, 2025

Detection of Protein S-Acylation using Acyl-Resin Assisted Capture
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Detection of Protein S-Acylation using Acyl-Resin Assisted Capture

Published on: April 10, 2020

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一个棕甲基转移酶化学遗传系统,用于映射ZDHHC特异性的S-化

Cory A Ocasio1, Marc P Baggelaar1,2,3, James Sipthorp1,2

  • 1The Francis Crick Institute, London, UK.

Nature biotechnology
|January 8, 2024
PubMed
概括

研究人员开发了一种新技术,用于绘制特定指Asp-His-His-Cys含基因 (ZDHHC) S-acyltransferases的蛋白质基板. 这种方法识别了300多个基质和S-化部位,推进了S-化生物学研究.

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Acyl-PEGyl Exchange Gel Shift Assay for Quantitative Determination of Palmitoylation of Brain Membrane Proteins

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Optimized Incorporation of Alkynyl Fatty Acid Analogs for the Detection of Fatty Acylated Proteins using Click Chemistry07:27

Optimized Incorporation of Alkynyl Fatty Acid Analogs for the Detection of Fatty Acylated Proteins using Click Chemistry

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相关概念视频

Covalently Linked Protein Regulators02:04

Covalently Linked Protein Regulators

Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
These groups modify specific amino acids in a protein....
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