Jove
Visualize
联系我们

相关概念视频

Standards of Care I01:22

Standards of Care I

Federal statutes profoundly impact nursing practice, providing critical guidelines to ensure patient care is equitable, accessible, and of the highest quality. The following laws address distinct aspects of healthcare provision and patient rights:
Standards of Care II01:19

Standards of Care II

Nurses bear specific legal responsibilities under several federal statutes, including:
Mechanical Ventilation II: Invasive Ventilation01:23

Mechanical Ventilation II: Invasive Ventilation

Ventilators are essential medical equipment used to aid patients with respiratory difficulties. Their primary function is to assist or replace spontaneous breathing by providing mechanical ventilation. There are two general classes of mechanical ventilators: negative-pressure and positive-pressure ventilators.
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...
Cardiac Catheterization IV: Nursing Management01:26

Cardiac Catheterization IV: Nursing Management

Nursing responsibilities before cardiac catheterization include:Assess for allergies and establish baseline health status.Before cardiac catheterization, assess the patient for allergies to contrast dye. Perform a comprehensive baseline assessment, including vital signs, heart and breath sounds, and a neurovascular assessment of the extremities, noting distal pulses, skin color, and temperature. Instruct the patient to fast for 8-12 hours before the procedure. Evaluate baseline laboratory...
Aortic Regurgitation IV: Nursing Management01:17

Aortic Regurgitation IV: Nursing Management

A nurse managing a patient with aortic regurgitation begins with a comprehensive assessment, including a review of the patient's medical history, family history, and lifestyle factors. During the cardiac examination, the nurse listens for heart sounds and checks for signs of valve abnormalities. The nurse also observes for symptoms such as dyspnea, orthopnea, and paroxysmal nocturnal dyspnea and assesses the patient's endurance and daily activity tolerance.Based on the findings, the nurse...
Varicose Veins II: Diagnostic Studies and Interprofessional Care01:26

Varicose Veins II: Diagnostic Studies and Interprofessional Care

Varicose veins, or varicosities, develop when the valves in the veins, which control blood flow, weaken or damage. It causes blood to pool and the veins to enlarge. Understanding the clinical manifestations, diagnostic approaches, and management options for varicose veins is crucial for effective treatment and relief.Clinical manifestationsClinical manifestations of varicose veins include a heavy, achy feeling or pain after prolonged standing or sitting. This discomfort can often be relieved by...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

The top-down Physiologically Based Finite Time Pharmacokinetic (PBFTPK) models open a new avenue for early drug development.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences·2026
Same author

The Finite Absorption Time Concept Guiding Model Informed Drug & Generics Development in Clinical Pharmacology.

Pharmaceutical research·2025
Same author

FDA and EMA Oversight of Disruptive Science on Application of Finite Absorption Time (F.A.T.) Concept in Oral Drug Absorption: Time for Scientific and Regulatory Changes.

Pharmaceutics·2024
Same author

Application of the Finite Absorption Time (F.A.T.) Concept in the Assessment of Bioequivalence.

Pharmaceutical research·2024
Same author

Revamping Biopharmaceutics-Pharmacokinetics with Scientific and Regulatory Implications for Oral Drug Absorption.

Pharmaceutical research·2023
Same author

Re-examining Naloxone Pharmacokinetics After Intranasal and Intramuscular Administration Using the Finite Absorption Time Concept.

European journal of drug metabolism and pharmacokinetics·2023
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关实验视频

Updated: Jul 17, 2026

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo
09:19

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo

Published on: February 6, 2015

8.7K

修订的IVIVC修订了

Nikolaos Alimpertis1,2, Antony Simitopoulos1, Athanasios A Tsekouras2,3

  • 1Faculty of Pharmacy, National and Kapodistrian University of Athens, Athens, Greece.

Pharmaceutical research
|January 8, 2024
PubMed
概括

本研究使用有限吸收时间 (F.A.T.) 修订了体外-体内相关性 (IVIVC). 和有限溶解时间 (F.D.T.) 这些概念. 概念. 概念. 新的方法揭示了药物吸收动力学,改善了对溶解过程的生理洞察力.

关键词:
IVIVC IVIVC IVIVC IVIVC IVIVC IVIVC IVIVC IVIVC IVIVC IVIVC IVIVC IVIVC IVIVC IVIVC IVIVC IVIVC IVIVC IVIVC IVIVC IVIVC IVIVC卡巴马西平是一种碳化合物.循环氨酸是一种环素.有限的吸收时间.有限溶解时间 有限溶解时间征税地块是一个征税地块.口服药物的吸收口服药物的吸收

更多相关视频

In Vivo Vascular Injury Readouts in Mouse Retina to Promote Reproducibility
07:35

In Vivo Vascular Injury Readouts in Mouse Retina to Promote Reproducibility

Published on: April 21, 2022

2.2K
In Vitro and In Vivo Evaluation of Photocontrolled Biologically Active Compounds - Potential Drug Candidates for Cancer Photopharmacology
13:17

In Vitro and In Vivo Evaluation of Photocontrolled Biologically Active Compounds - Potential Drug Candidates for Cancer Photopharmacology

Published on: September 29, 2023

2.4K

相关实验视频

Last Updated: Jul 17, 2026

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo
09:19

Evaluating the Effectiveness of Cancer Drug Sensitization In Vitro and In Vivo

Published on: February 6, 2015

8.7K
In Vivo Vascular Injury Readouts in Mouse Retina to Promote Reproducibility
07:35

In Vivo Vascular Injury Readouts in Mouse Retina to Promote Reproducibility

Published on: April 21, 2022

2.2K
In Vitro and In Vivo Evaluation of Photocontrolled Biologically Active Compounds - Potential Drug Candidates for Cancer Photopharmacology
13:17

In Vitro and In Vivo Evaluation of Photocontrolled Biologically Active Compounds - Potential Drug Candidates for Cancer Photopharmacology

Published on: September 29, 2023

2.4K

科学领域:

  • 药理动力学 药理动力学
  • 药物的溶解和吸收.

背景情况:

  • 在体外-体内相关性 (IVIVC) 对于预测药物性能至关重要.
  • 现有的IVIVC模型可能无法完全捕捉药物吸收和溶解的生理复杂性.
  • 有限吸收时间 (F.A.T.) 和有限溶解时间 (F.D.T.) 提供一个更健康的生理框架.

研究的目的:

  • 修改现有的IVIVC方法.
  • 将F.A.T.的生理学相关概念纳入其中. 和 F.D.T.T. 在一起. 在IVIVC中.
  • 提高对药物溶解和吸收过程的了解.

主要方法:

  • 开发了一个修改后的Levy图表,其中包含了FAT的估计. (τ) 和 F.D.T.T. 的时间. (τd) 在此之前.
  • 应用生理学基础的药理动力学 (PBFTPK) 模型来分析药物吸收动力学.
  • 重新分析了carbamazepine的生物等价性研究数据,并评估了theophylline溶解.

主要成果:

  • 修改后的Levy图表突出显示了体外溶解 (≈2小时) 和体内吸收 (≈17小时) 持续时间之间的差异.
  • PBFTPK模型证实了碳二的复杂,多阶段的吸收过程.
  • 在经过修改的Levy和IVIVC图片中观察到非线性关系,用于卡巴马泽.

结论:

  • 整合F.A.T.的方法 和 F.D.T.T. 在一起. 这些概念进入了Levy图片和IVIVC,提供了更深入的生理洞察力.
  • 这种修订后的方法改善了对体外和体外药物溶解和吸收的理解.
  • 这些发现支持基于溶解数据更准确地预测药物行为.