诊断与癌症相关的缺血性中风:血液学生物标志物的系统审查
Mai Erritzøe-Jervild1,2, Jonathan Wenstrup1,3,4, Bjørn Holger Hougaard5
1Department of Neurology, Neurovascular Research Unit, Copenhagen University Hospital-Herlev Gentofte, Copenhagen, Denmark.
概括
升高的D-二聚物水平与癌症患者的缺血性中风 (IS) 有关. C-反应蛋白 (CRP) 也可能表明与癌症相关的中风,但需要更多的研究来确认.
科学领域:
- 生物标志物 生物标志物
- 在瘤学瘤学.
- 神经学 神经学
背景情况:
- 癌症患者面临较高的缺血性中风 (IS) 风险.
- 从临床上来说,区分与癌症相关的IS与其他原因是非常重要的.
- 确定可靠的与癌症相关的IS生物标志物是一个关键的研究领域.
研究的目的:
- 识别和评估与癌症相关的生物标志物,这些生物标志物可以区分癌症患者的IS和非癌症患者的IS.
- 系统地审查有关癌症相关IS生物标志物的现有文献.
主要方法:
- 在PubMed和EMBASE数据库上进行了系统的文献搜索.
- 根据系统审查和元分析 (PRISMA) 准则的首选报告项目进行了选.
- 分析了49项选定研究的数据,以确定相关的生物标志物.
主要成果:
- 七个生物标志物显示出区分与癌症相关的IS的潜力.
- 在42/44的研究中,D-二聚合物是最常被研究的生物标志物,高水平与与癌症相关的中风有显著联系.
- 在19项研究中,C-反应蛋白 (CRP) 与癌症相关的中风有关,但需要进一步的多变量分析. 纤维素原和特定癌症抗原 (CA125,CA153,CA199,CEA) 的相关性不太一致.
结论:
- D-二聚合物水平升高似乎与与癌症相关的缺血性中风有显著的关联.
- C-反应蛋白 (CRP) 是癌症相关中风的潜在候选生物标志物,需要进一步调查.
- 纤维素和特定的癌症生物标志物尚未被确地证明对检测癌症相关中风有帮助.
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