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库尔库明-β-环氧氨酸分子包容复合物:一种水溶性复合物,用于治疗神经退行性疾病的快速溶解片

Sruthi Laakshmi Mugundhan¹, Purushothaman Balasubramaniyan¹, Damodharan Narayanasamy¹

¹Department of Pharmaceutics, SRM College of Pharmacy, SRM Institute of Science and Technology, Kattankulathur, India.

Pharmaceutical nanotechnology

|January 9, 2024

概括

这项研究开发了用于神经退行性疾病的快速溶解的库尔库明-β-环氧氨酸纳入复合物的口服片. 优化的配方与粉糖酸盐和Neusilin® ULF2证明了黄素溶解和分解时间的增强.

科学领域:

制药科学制药科学
药物输送系统药物输送系统
材料科学材料科学材料科学

背景情况:

口服分解片 (ODT) 为药物输送提供了更好的口感.
黄素对神经退行性疾病的治疗潜力受到其溶解性差的限制.
包装β-cyclopodextrin增强了黄素通过其疏水性腔的溶解性.

研究的目的:

设计,配方,并优化快速溶解的口服药片的库尔库-β-环极含复合物.
为了研究配方变量对平板电脑特性的影响,使用32因素设计.

主要方法:

通过溶剂造制备的库尔库明-β-环氧胺含复合物,具有XRD的特征.
使用FTIR光谱学评估的药物辅助剂兼容性.
使用32因素设计优化药片配方,评估粉糖酸盐 (X1) 和Neusilin® ULF2 (X2) 对分解和溶解的影响.

主要成果:

所有压缩后的参数 (硬度,厚度,重量变化,易碎性,浸湿时间,药物含量) 都在可接受的范围内.
解体时间在45-58秒之间.
较高度的粉糖和Neusilin® ULF2显著增强了黄素的*体外*释放.

结论:

经过验证的黄素-β-环氧素含有复杂的快溶性药片已成功开发.
优化的配方,包括粉糖酸盐和Neusilin® ULF2,是治疗神经退行性疾病的有希望的方法.
这种配方为库尔库提供了有效的口服输送系统.

关键词:

纽西林ULF2的使用情况库尔库明是一种黄素.快溶性口服药片快溶性口服药片粉糖酸盐是一种粉糖酸盐.溶解度. 溶解度. 在水中溶解.这是一种β-cyclodextrin.

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