蛋白质输送系统的挑战和治疗方法:一篇综述
Devashish Jena1, Nimisha Srivastava1, Iti Chauhan2
1Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow, Sector 125, Noida, 201313, India.
Pharmaceutical nanotechnology
|January 9, 2024
概括
蛋白质输送系统提供了新的治疗选择,通过多种管理途径和先进的策略克服生物障碍,如Pegylation. 本综述探讨了蛋白质功能,输送挑战以及用于增强药物配方的创新解决方案.
科学领域:
- 生物技术是生物技术.
- 制药科学 制药科学
- 药物输送系统 药物输送系统
背景情况:
- 蛋白质是重要的生物分子,调节许多生理功能,使它们成为关键的治疗剂.
- 蛋白疗法在制药和生物技术行业中是一个快速增长的行业.
- 有效的输送系统对于充分利用基于蛋白质的药物的全部潜力至关重要.
研究的目的:
- 审查蛋白质在人体中的基本作用.
- 探索蛋白质疗法的各种管理途径,包括传统和替代方法.
- 讨论克服蛋白质输送中的生物障碍的重大挑战和创新策略.
主要方法:
- 关于蛋白质功能,药物输送系统和施用途径的文献综述.
- 在蛋白质药物输送中遇到的障碍的分析 (酶,上皮,内皮,血脑障碍).
- 检查克服这些障碍的战略,包括化学修饰和先进技术.
主要成果:
- 亲肠道途径 (静脉注射,肌肉内注射,皮下注射) 是常见的,但其他途径 (口腔,鼻子,透皮) 是有前途的.
- 生物障碍对有效的蛋白质药物输送构成重大挑战.
- 化学修饰,透增强剂,粘膜聚合物,Pegylation和Depofoam技术是关键策略.
结论:
- 蛋白质输送系统对于促进蛋白质的治疗应用至关重要.
- 克服生物障碍对于成功的蛋白质药物配方和管理至关重要.
- 像Pegylation和Depofoam这样的新兴技术显著提高了蛋白质递送的有效性.
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