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多模纳米颗粒含有改性酸酸基聚合物合物,用于减轻严重炎症的免疫功能障碍

Nhu Truong¹, Andrea L Cottingham¹, Shruti Dharmaraj¹

¹Department of Pharmaceutical Sciences University of Maryland School of Pharmacy Baltimore Maryland USA.

Bioengineering & translational medicine

|January 9, 2024

概括

这项研究开发了新型纳米颗粒,装载着 histone deacetylase 抑制剂 (SAHA-OH),用于对抗败血症. 新配方iNP-SAHA在毒症小鼠模型中降低了有害的炎症并改善了生存率.

科学领域:

免疫学免疫学免疫学
纳米技术纳米技术
药理学药理学是指药理学的学科.

背景情况:

严重的炎症和败血症涉及复杂的免疫失调,过度的免疫激活和抑制.
基因组脱乙酶抑制剂 (HDACi) 显示出免疫调节的潜力,但受控的分娩仍然是一个挑战.

研究的目的:

开发和评估新型免疫调节纳米颗粒 (iNP-SAHA) 用于控制素脱乙酶抑制剂 (SAHA-OH) 的输送.
调查iNP-SAHA在减少炎症和改善败血症临床前模型中的存活率方面的治疗疗效.

主要方法:

用SAHA-OH对聚乳-协同甘油酸 (PLGA) 进行共价修饰,以产生前药纳米粒子 (iNP-SAHA).
在体外评估巨细胞存活率和细胞因子/基因表达在脂多糖 (LPS) 挑战下.
在致命的LPS诱导的内毒毒性败血症小鼠模型中对iNP-SAHA的体内评估,评估生存率,血细胞因子/化学因子水平和器官毒性.

主要成果:

iNP-SAHA证明了SAHA-OH的受控释放,提高了巨细胞的存活率,并减少了促炎性细胞因子和基因表达.
在毒症小鼠模型中,iNP-SAHA的使用显著改善了剂量依赖的生存率.
iNP-SAHA有效地降低了血的促炎细胞因子和化学因子,并减轻了与败血症相关的脏和肝脏毒性.

结论:

iNP-SAHA代表了一种有前途的药物输送系统,用于调节败血症的多面性炎症反应.
iNP-SAHA的多药性活性为复杂的炎症性疾病提供了潜在的治疗策略.

关键词:

药物输送是药物输送的过程.基因素脱乙酶抑制剂基因素脱乙酶抑制剂这是一种炎症炎症炎症炎症.脂多糖因子诱导的内毒症.纳米颗粒是一种纳米粒子.这是一种血症.

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