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人体腹部的超极化C代谢成像与时空无声化

Tanner M Nickles^1,2, Yaewon Kim¹, Philip M Lee^1,2

¹Department of Radiology & Biomedical Imaging, University of California San Francisco, San Francisco, California, USA.

Magnetic resonance in medicine

|January 9, 2024

概括

这项研究引入了一种无声化方法,以增强腹部超极化C核磁共振扫描. 该技术可以改善关键代谢物的可视化和量化,有助于研究胰腺癌.

科学领域:

医疗成像医学成像
生物物理学的生物物理.
生物化学生化学

背景情况:

超极化 (HP) C MRI提供了动态的代谢洞察力.
腹部HP ¹³ C MRI面临信号噪声比 (SNR) 和图像保真性的挑战.
现有的拒绝方法可能会损害重要的定量信息.

研究的目的:

开发和验证基于补丁的全球-本地更高阶奇数值分解 (GL-HOVSD) 方法,用于时空无声化.
为了提高图像质量和保持大范围腹部HP¹³CMRI的数据保真度.
为了提高腹部HP13CMRI研究中的代谢物的可视化和量化.

主要方法:

使用模拟的[1-¹³ C]pyruvate动力学在各种噪声水平上评估消噪性能,以优化k_全球和k_本地参数.
将优化的GL-HOVSD方法应用于来自健康志愿者 (n=7) 和胰腺癌患者 (n=8) 的腹部HP[1-¹³ C]pyruvateEPI数据.
使用根平均平方误差 (RMSE) 和代谢物转换率 (k_PX) 评估图像保真度.

主要成果:

优化的参数 (k_global=0.2,k_local=0.9) 可以有效地消除数据,同时保持图像保真 (低RMSE).
代谢物转化率 (k_PX) 在足够的SNR (SNR_AUC > 5) 时,与基本真相有20%的差异.
在明显的SNR_AUC中实现了>9倍的增加,用于[1-¹³ C]pyruvate,[1-¹³ C]lactate和[1-¹³ C]alanine.
在k_PL和k_PA量化图表中,可靠安装的voxel分别增加了2.1倍和4.8倍.

结论:

时空无色化显著增强了低SNR代谢物的可视化,特别是[1-¹³ C]alanine.
GL-HOVSD方法使[1-¹³ C]pyruvate代谢在大型FOV腹部HP¹³CMRI中能够更稳定地量化.
这种方法有望改善腹部HP¹³CMRI研究中的诊断能力.

关键词:

腹部成像 - - 腹部成像氨酸氨酸是什么意思碳-13是什么意思?碳-13是什么意思更高阶的单数值分解.过极化的超极化图像去色化图像去色化胰腺胰腺是什么皮鲁酸是一种酸盐.

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