相关实验视频

Updated: Jul 6, 2025

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Published on: May 22, 2020

一种基于氧化的免疫能力强的毒刺纳米激动剂用于癌症放射免疫疗法

Yuhua Cao¹, Shuaishuai Ding¹, Yunping Hu¹

¹Institute of Pathology and Southwest Cancer Center, The First Affiliated Hospital, Third Military Medical University (Army Medical University), and Key Laboratory of Tumor Immunopathology Ministry of Education of China, Chongqing 400038, P. R. China.

|January 9, 2024

概括

这项研究引入了一种新的纳米粒子,该纳米粒子将放射敏感化与cGAS-STING通路激活相结合. 这种方法通过与检查点抑制剂相结合,通过增强对瘤的免疫反应来增强癌症免疫疗法.

科学领域:

在瘤学瘤学.
纳米技术纳米技术
免疫学免疫学免疫学

背景情况:

cGAS-STING信号传递对于放射治疗诱导的免疫调节至关重要.
仅仅放射治疗在安全的X射线剂量下维持瘤内STING激活的局限性.

研究的目的:

开发一种辐射敏感化策略,与cGAS刺激合作,用于增强癌症免疫治疗.
为了设计一个核心外纳米结构,将放射敏感剂与cGAS-STING激动剂结合起来.

主要方法:

一个核心外纳米粒子与氧化 (HfO2) 核心和氧化 (MnO2) 外的制造.
HfO2核心用于放射敏感化,MnO2外用于持续释放离子 (Mn2+) 和cGAS激活.
评估放射敏感化和STING激活在受辐射瘤中的协同效应.

主要成果:

通过HfO2介导的放射敏感化增加了免疫细胞死亡,产生瘤抗原和细胞质DNA.
可持续释放的Mn2+,增强了cGAS的识别能力.
同步释放的Mn2+和DNA损伤协同促进了cGAS-STING激活,改善了放射治疗结果.

结论:

同步辐射敏感化和持续的STING激活是一种强大的免疫刺激策略.
这种方法优化了癌症放射性免疫疗法,特别是当与免疫检查点抑制剂相结合时.

关键词:

氧化哈夫尼的氧化物免疫刺激免疫刺激放射性免疫疗法是一种放射性免疫疗法.放射性敏感化是一种放射性敏感化.cGAS-STING路径的使用.

更多相关视频

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?

Published on: June 13, 2014

Synthesis of Immunotargeted Magneto-plasmonic Nanoclusters

Synthesis of Immunotargeted Magneto-plasmonic Nanoclusters

Published on: August 22, 2014

相关概念视频

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

Cancer Therapies

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...