相关实验视频

Updated: Jul 6, 2025

Thermal Imaging to Study Stress Non-invasively in Unrestrained Birds
10:07

Thermal Imaging to Study Stress Non-invasively in Unrestrained Birds

Published on: November 6, 2015

13.5K

葡萄糖皮质体和上腺素受体在人体器官和组织中的分布:压力转导的地图

Sophia Basarrate1, Anna S Monzel, Janell L M Smith

  • 1From the Division of Behavioral Medicine, Department of Psychiatry (Basarrate, Monzel, Smith, Trumpff, Picard), Columbia University Irving Medical Center, New York, New York; Department of Psychology (Marsland), University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Neurology, H. Houston Merritt Center, Columbia Translational Neuroscience Initiative (Picard), Columbia University Irving Medical Center; and New York State Psychiatric Institute (Picard), New York, New York.

Psychosomatic medicine
|January 9, 2024
PubMed
概括

这项研究绘制了整个人体内的葡萄糖皮质体受体 (GR) 和上腺体受体 (AR) 表达的地图. 研究结果将受体模式与线粒体能量通路联系起来,这可能解释器官系统对压力的脆弱性.

更多相关视频

Isolation, Fixation, and Immunofluorescence Imaging of Mouse Adrenal Glands08:37

Isolation, Fixation, and Immunofluorescence Imaging of Mouse Adrenal Glands

Published on: October 2, 2018

24.0K
Primary Culture of Rat Adrenocortical Cells and Assays of Steroidogenic Functions04:33

Primary Culture of Rat Adrenocortical Cells and Assays of Steroidogenic Functions

Published on: March 12, 2019

8.1K

相关概念视频

Hormones of the Adrenal Glands01:31

Hormones of the Adrenal Glands

Adrenal hormones play a pivotal role in maintaining the body's electrolyte balance and orchestrating responses to stress, showcasing the intricate functions of the adrenal cortex and medulla.
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and...
2.5K
Anatomy of the Adrenal Glands01:17

Anatomy of the Adrenal Glands

The adrenal or supra-renal glands, situated above the kidneys and aligned with the twelfth rib, are paired pyramid-shaped structures crucial for the body's stress response. During stress, these glands secrete hormones vital for adaptive physiological reactions.
These glands possess a distinctive yellow tinge due to the stored cholesterol and fatty acids required for hormone synthesis. They are encased in a fibrous capsule and cushioned by fat.
The adrenal gland comprises two distinct...
2.2K
Physiological Foundation of Stress01:24

Physiological Foundation of Stress

Stress triggers a coordinated physiological response involving the sympathetic nervous system (SNS) and the hypothalamic-pituitary-adrenal (HPA) axis. This dual activation ensures that the body is prepared for both immediate and prolonged stress management. The process begins with the perception of a stressor. This initial phase activates the SNS, leading to the rapid release of adrenaline (epinephrine) from the adrenal glands.
Role of the Sympathetic Nervous System
Adrenaline triggers the...
59
Hypothalamic-Pituitary Axis01:37

Hypothalamic-Pituitary Axis

The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
60.1K
Sympathetic Signaling01:32

Sympathetic Signaling

Sympathetic signaling, a vital part of the autonomic nervous system, plays a crucial role in mobilizing the body's resources in response to stress or emergencies. It involves the transmission of nerve impulses from sympathetic preganglionic fibers to postganglionic fibers. This results in the release of specific neurotransmitters and activation of adrenergic receptors.
Sympathetic preganglionic fibers release the neurotransmitter acetylcholine (ACh) onto the ganglionic neurons in the...
963
Adrenergic Receptors: β Subtype01:26

Adrenergic Receptors: β Subtype

β-adrenoceptors have varied sensitivities towards adrenaline, noradrenaline, and isoprenaline. The order of agonist potency is as follows:
Isoprenaline > Adrenaline > Noradrenaline
Neurotransmitter binding to these receptors causes activation of adenylyl cyclase resulting in increased concentrations of cAMP and modulation of calcium ion channels within the cell. They are further classified into β1, β2, and β3 subtypes.
β1-adrenoceptors: β1-adrenoceptors...
1.7K