与脂肪性肝病相关的代谢功能障碍的治疗管理
Jing Zeng1,2, Jian-Gao Fan1,2, Sven M Francque3,4
1Department of Gastroenterology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
United European gastroenterology journal
|January 9, 2024
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD),以前称为NAFLD,在全球范围内正在上升. 早期检测和生活方式的改变是关键,新的药物正在出现治疗.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 代谢障碍 代谢障碍 代谢障碍
- 心血管健康 心血管健康
背景情况:
- 非酒精性脂肪肝疾病 (NAFLD) 现在是代谢功能障碍相关的脂肪肝炎 (MASH).
- MASLD是代谢和炎症压力的结果,通常与脂肪组织功能障碍和胰岛素抵抗有关.
- 先进的MASH具有有限的治疗选择,强调了早期干预的必要性.
研究的目的:
- 审查目前对MASLD/MASH的理解和管理.
- 强调早期检测和多学科护理的重要性.
- 讨论现有和新兴药理疗法的作用.
主要方法:
- 关于MASLD/MASH研究和临床实践近期进展的文献综述.
- 分析代谢综合征对肝脏健康的影响.
- 评估当前的治疗策略,包括改变生活方式,减肥手术和药物治疗.
主要成果:
- 改变生活方式仍然是MASLD管理的基石.
- 腹腔外科手术是选择患者的可行选择.
- 现有的心脏代谢药物显示出减缓MASH进展的潜力,预计将很快推出MASH特异性药物.
结论:
- MASLD/MASH需要采用多学科的方法,认识到它在心血管-肝脏-代谢综合征中的核心作用.
- 优化目前的药物使用和为新的MASH特定疗法做准备至关重要.
- 对于MASH肝硬化治疗,需要进一步的研究.
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