克洛托蛋白,维生素D和氧化应激参数对尿路结石的形成和复发的影响
Emin Gürtan1, Levent Işıkay2, Ayşe Yeşim Göçmen3
1Department of Urology, Bayburt State Hospital, Tuzcuzade District Barbaros Street Number: 11, Center/Bayburt, Bayburt, 69000, Turkey. emin_gurtan@hotmail.com.
International urology and nephrology
|January 9, 2024
概括
阿尔法-克洛托和像MDA这样的氧化应激标志物参与尿路结石疾病 (USD) 病变. 这些生化标志物可以帮助在临床实践中识别患有首次或复发性USD风险的患者.
科学领域:
- 生物化学 生物化学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 尿路结石病 (USD) 是一个重大的健康挑战.
- 了解美元的生化基础对于有效管理至关重要.
- 氧化应激在各种疾病中起作用,包括结石形成.
研究的目的:
- 调查alpha-Klotho和氧化应激标记在尿路结石病 (USD) 中的作用.
- 评估alpha-Klotho,malondialdehyde (MDA) 和氧化应激指数 (OSI) 作为美元的潜在生化标志物.
- 评估这些标记在区分首次和经常性美元的有用性.
主要方法:
- 研究了90名个体的队列,分为健康对照组,首次USD患者和经常性USD患者.
- 测量了阿尔法-克洛托,维生素D,MDA,总氧化剂状态和总抗氧化剂状态的血清水平.
- 还分析了血清,副激素和24小时尿液水平.
主要成果:
- 在各组之间观察到alpha-Klotho,OSI,MDA和24小时尿液的显著差异.
- 阿尔法-克洛托水平与24小时尿液和OSI相反相关.
- 特定的alpha-Klotho值表现出适度的灵敏度和特异性,用于识别首次和反复的USD.
结论:
- 阿尔法-克洛托,OSI和MDA都与尿路结石形成的病变有关.
- 这些生化标志物显示出在泌尿病学中临床应用的前景.
- 它们可以帮助识别患有初始和复发性USD.发作风险的患者.
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