相关实验视频

Updated: Jul 6, 2025

The Transition to an Anterior-Based Muscle Sparing Approach Improves Early Postoperative Function but is Associated with a Learning Curve

The Transition to an Anterior-Based Muscle Sparing Approach Improves Early Postoperative Function but is Associated with a Learning Curve

Published on: September 7, 2022

全关节整形术后的抗血栓预防:一级I贝叶斯网络元分析

Filippo Migliorini^1,2,3, Nicola Maffulli^4,5,6, Erlis Velaj⁷

¹Department of Orthopaedic, Trauma, and Reconstructive Surgery, RWTH University Medical Centre, Pauwelsstraße 30, 52074, Aachen, Germany. migliorini.md@gmail.com.

Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology

|January 9, 2024

概括

阿皮克萨班5毫克为预防静脉血栓塞栓症 (VTE) 和控制关节整形术 (THA) 后的出血提供了最佳平衡. 这一发现有助于选择VTE的最佳药理学预防.

科学领域:

整形外科手术整形外科手术
药理学药理学是指药理学的学科.
基于证据的医学基于证据的医学.

背景情况:

在关节整形术 (THA) 后的静脉血栓栓塞 (VTE) 预防缺乏关于最佳药理学药物的最终共识.
现有的临床研究对不同静脉瘤预防策略的有效性和安全性提出了不同的发现.

研究的目的:

为了比较埃诺沙巴林,芬达帕鲁努克斯,阿司匹林和非维生素K抗剂口服抗凝剂 (NOACs) 的疗效和安全性,用于THA后的VTE预防.
为了确定在VTE预防和出血风险之间取得最佳平衡的药物.

主要方法:

进行了贝叶斯网络元分析,遵循PRISMA扩展指南的网络元分析.
在2023年3月,随机对照试验 (RCT) 对THA后的VTE预防药物进行比较,在PubMed,Web of Science和Google Scholar数据库中进行了系统的搜索.
评估的结果包括深静脉血栓塞 (DVT),肺栓塞 (PE) 和大/小出血的发生率.

主要成果:

阿皮克萨班5毫克,芬达巴林克斯和里瓦罗克萨班60毫克在降低DVT发病率方面显示出最高的疗效.
达比加特兰220毫克,阿皮克萨班5毫克和阿司匹林100毫克在降低PE方面最有效.
5毫克的阿皮克萨班,2毫克的西米拉加特兰和100毫克的阿司匹林与较低的重大出血率有关,而2.5毫克的里瓦罗克萨班,5毫克的阿皮克萨班和40毫克的埃诺沙巴林则是较低的轻微出血率.

结论:

5毫克的阿皮克萨班证明了在THA之后,对VTE预防和出血控制最有利的概况.
该研究提供了基于RCT网络元分析的I级证据,支持阿皮克萨班5毫克作为THA后VTE预防的主要选择.

关键词:

抗血栓性预防抗血栓性预防深静脉血栓形成的原因是深静脉血栓.发生出血发生出血肺栓塞肺栓塞是一种肺栓塞.整体关节整形术关节整形术

更多相关视频

Individualized Stem-positioning in Calcar-guided Short-stem Total Hip Arthroplasty

Individualized Stem-positioning in Calcar-guided Short-stem Total Hip Arthroplasty

Published on: February 27, 2018

Treatment of Ankle Osteoarthritis with Total Ankle Replacement Through a Lateral Transfibular Approach

Treatment of Ankle Osteoarthritis with Total Ankle Replacement Through a Lateral Transfibular Approach

Published on: January 24, 2018

相关概念视频

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
Prostaglandin synthesis inhibitors, exemplified by the widely known aspirin, wield their power by irreversibly acetylating...