在患有自身免疫性脑炎的患者中,发症和直肠痛的突然意外死亡:系统性审查
Alberto Vogrig1,2, Fabrizio Bellizzi3, Alessandra Burini3
1Clinical Neurology, Department of Medicine (DAME), University of Udine, Udine, Italy. alberto.vogrig@uniud.it.
概括
自身免疫性脑炎 (AE) 与 (SUDEP) 和角膜 (IA) 中的突然意外死亡有关,这表明边缘系统参与. 早期诊断和治疗至关重要,特别是对于患有叶的女性患者.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 心脏病学 心脏病学
背景情况:
- 自身免疫性脑炎 (AE) 经常影响 mesial 时结构.
- 这些结构与的突然意外死亡 (SUDEP) 和阴道 (IA) 有关.
- AE可以作为研究SUDEP和IA的病理生理学的潜在模型.
研究的目的:
- 系统地审查AE患者中SUDEP和IA的发生情况.
- 探索AE与这些致命/近乎致命事件之间的潜在联系.
主要方法:
- 在2022年12月20日之前对4个数据库 (MEDLINE,Scopus,Embase,Web of Science) 进行系统审查.
- 在研究选择过程中遵循了PRISMA指南.
- 包括在AE患者中报告SUDEP,近SUDEP或IA的文章.
主要成果:
- 包括11个案例:7个是SUDEP/近SUDEP,4个是IA.
- IA主要影响女性; SUDEP发生在AE发作后11个月的中位延迟,IA在0.9个月.
- 所有IA病例和2个SUDEP病例都是抗体阳性;新发作和认知/精神症状是常见的.
结论:
- SUDEP和IA与AE有关,涉及到边缘系统的病变发生.
- 在AE中,阴道缩通常出现在早期叶发作的女性中.
- 强调需要迅速诊断和管理AE以减轻风险.
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