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在β2上腺素受体的突变变体中产生偏差信号:从分子动力学模拟的见解

Midhun K Madhu1, Kunal Shewani2, Rajesh K Murarka2

  • 1Department of Biological Sciences, Indian Institute of Science Education and Research Bhopal, Bhopal Bypass Road, Bhopal, Madhya Pradesh 462066, India.

Journal of chemical information and modeling
|January 9, 2024
PubMed
概括

分子动力学模拟揭示了β2-上腺素受体 (β2AR) 的突变如何改变信号通路. 这些发现揭示了受体偏差机制,有助于设计具有较少副作用的向疗法.

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