闭环胰岛素输送可能有助于预防1型糖尿病患者减肥手术期间的代谢并发症:病例报告
Erika Cornu1, Camille Gaulier2, Pauline Juttet1
1Department of Endocrinology and Medipole, Lyon Villeurbanne, Villeurbanne, France.
Diabetes technology & therapeutics
|January 9, 2024
概括
1型糖尿病患者的肥胖症对减肥手术构成风险. 闭环胰岛素输送系统可以减轻低血糖症等并发症,为这一群体提供更安全的手术程序.
科学领域:
- 内分泌学 在内分泌学.
- 代谢手术 代谢手术
- 糖尿病管理 糖尿病管理
背景情况:
- 肥胖使1型糖尿病 (T1D) 的管理和预后复杂化.
- 在T1D患者的腹腔外科手术具有风险,包括糖尿病酸性脂肪酸症和严重的低血糖症.
- 闭环胰岛素输送系统为高风险手术期间管理血糖控制提供了潜在的解决方案.
研究的目的:
- 评估T1D和肥胖症患者接受空腹手术的闭环胰岛素输送的安全性和有效性.
- 评估闭环胰岛素供应在预防外科手术期间血糖并发症方面的可行性.
主要方法:
- 一名45岁的女性患者患有T1D和肥胖 (BMI 38.4 kg/m2) 被纳入.
- 关闭循环胰岛素的输送是在减肥手术前三个月开始的,因为有严重低血糖病史.
- 对术后血糖控制和不良事件进行了监测.
主要成果:
- 患者没有经历过即时或晚期的术后低血糖症,即使减少了碳水化合物摄入量.
- 血糖控制成功维持,在手术后三个月内,血糖控制范围 (70-180 mg/dL) 的时间为86%.
- 手术后没有记录过低血糖 (血糖<70 mg/dL) 的情况.
结论:
- 闭环胰岛素输送有助于在患有T1D和肥胖症的患者中安全执行减肥手术.
- 这项技术似乎是一个可行的策略,用于预防这个高风险队列的外科手术期低血糖症.
- 需要进一步的研究来证实闭环系统在类似患者群体中的好处.
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