奇孔古尼亚病毒感染会通过MARCO破坏淋巴结的淋巴内皮细胞组成和功能
Cormac J Lucas1,2, Ryan M Sheridan2, Glennys V Reynoso3
1Department of Immunology & Microbiology and.
JCI insight
|January 9, 2024
概括
奇孔古尼亚病毒 (CHIKV) 感染通过向淋巴内皮细胞 (LECs) 来破坏淋巴结组织. CHIKV-MARCO相互作用加速炎症并损害关键的LEC功能,如抗原获取.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 细胞生物学 细胞生物学
背景情况:
- 奇孔古尼亚病毒 (CHIKV) 感染破坏了排水淋巴结 (dLN) 组织.
- 这种干扰包括B细胞的重新定位,B细胞-T细胞边界的丧失和淋巴细胞的枯竭.
- 在CHIKV感染期间,炎症性髓状细胞透到淋巴结.
研究的目的:
- 研究CHIKV与淋巴结内淋巴内皮细胞 (LEC) 之间的早期相互作用.
- 了解这些相互作用如何影响淋巴结的炎症反应和感染期间的整体功能.
主要方法:
- 追踪CHIKVRNA积累在LN鼻腔中的MARCO表达的LEC中.
- 分析LN stromal细胞中的基因表达变化.
- 评估CHIKV-MARCO相互作用对炎症反应和髓状细胞招募的影响.
- 在CHIKV感染期间量化LEC数量并评估LECs对抗原的获取.
主要成果:
- 在24小时内,CHIKVRNA积累在地板和骨髓LN鼻腔中的MARCO表达的LEC中.
- 病毒RNA的积累在LN stromal细胞中触发了抗病毒和炎症基因程序.
- CHIKV-MARCO相互作用加速了炎症反应和髓状细胞的招募.
- 奇克病毒感染导致地板和骨髓LEC的减少,并降低了它们的抗原获取功能.
结论:
- 淋巴结中LEC是CHIKV感染的早期目标.
- CHIKV-MARCO相互作用驱动淋巴结炎症和功能障碍.
- 在CHIKV感染期间,受损的LEC功能损害了关键的免疫监测机制.
相关概念视频
01:29Immune Response Against Viral Pathogens
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
01:25Arboviral Encephalitis
Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
01:18Yellow Fever
Yellow fever is a viral hemorrhagic disease caused by the yellow fever virus (YFV), a member of the Flaviviridae family. It is transmitted primarily by Aedes and Haemagogus mosquitoes in tropical and subtropical regions of Africa and South America. After transmission through a mosquito bite, the virus initially replicates in skin-resident immune cells such as dendritic cells and macrophages. These cells then migrate to the lymph nodes, where viral replication increases, eventually leading to...
01:27Cytomegalovirus Disease
Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
01:26Encephalitis ll: Pathophysiology
Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...