路径选择性光遗传学揭示了的视觉皮层中自上而下的注意力调制的功能解剖学
Janina Hüer1,2, Pankhuri Saxena1, Stefan Treue1,3,4,5
1Cognitive Neuroscience Laboratory, German Primate Center, Leibniz Institute for Primate Research, Göttingen 37077, Germany.
概括
前视野 (FEF) 通过其投射直接影响MT区域的视觉处理. 这一途径增强了对目标的注意力,并抑制了分心因素,澄清了空间注意力机制.
科学领域:
- 神经科学是一个神经科学.
- 灵长类动物的视力
- 认知神经科学 认知神经科学
背景情况:
- 空间注意力是一个关键的自上而下的过程,调节灵长类动物视觉皮层中的感觉反应.
- 前视野 (FEF) 是这种注意力调节的潜在来源.
- 目前尚不清楚FEF对视觉区域的确切途径和影响 (增强/抑制).
研究的目的:
- 调查FEF是否通过直接投射来调节视觉区域MT.
- 为了确定FEF是否会影响辅导刺激的增强和无辅导刺激的抑制.
- 阐明直接FEF到MT路径在空间注意力中的作用.
主要方法:
- 路径选择性光遗传学是在空间注意力任务期间在 rhesus macaques 中使用的.
- 从FEF到视觉区域MT的直接输入被光遗传抑制.
- 在MT区域记录和分析了神经元反应.
主要成果:
- 对FEF输入到MT的光遗传抑制减少了大约33%的注意调制.
- MT神经元的感觉响应组件不受抑制的影响.
- 直接的FEF-to-MT途径被证明有助于目标增强和分心抑制.
结论:
- 在视觉区域MT,FEF可以选择性调节火速.
- 这种调制特别通过FEF到MT的直接轴突突出的投影发生.
- 从FEF到MT的直接路径在实现空间注意力方面发挥着至关重要的作用.
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