焦点的皮质大脑响应神经刺激:一个单一中心的经验
David Burdette1, Sanjay Patra1, Lise Johnson2
1Corewell Health and Michigan State University College of Human Medicine, Grand Rapids, Michigan, U.S.A.; and.
概括
针对前部,中部或中脉质核的响应性神经刺激有效地减少了耐药性的发作. 高频和低频都被证明是有益的,为塔拉米神经调节提供了新的见解.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 生物医学工程 生物医学工程
背景情况:
- 泰拉马斯与其广泛的大脑连接是药物耐药焦点中神经调节的关键目标.
- 皮质体的刺激可以调节皮质体和皮质体的发作发作区域.
- 针对发症的深度导向针对特定的乳头核 (前部,中枢,脉) 的临床数据有限.
研究的目的:
- 为了评估皮质体回应神经刺激的疗效和结果,针对前部 (ANT),中枢,或脉 (PUL) 核在耐药焦点患者.
- 为了比较临床结果和电生理学特征在不同的thalamic目标.
主要方法:
- 一个单一中心的回顾性研究,涉及19名耐药焦点患者.
- 利用RNS系统进行响应性神经刺激,针对ANTT,中位点或PUL的胸膜核.
- 详细的目标选择方法,设备编程和临床和电生理学数据分析.
主要成果:
- 响应性皮质体内神经刺激在79%的患者中是有效的,使得残疾性发作频率减少了≥50%.
- 26%的患者在致残性发作频率上有≥90%的降低.
- 使用高 (≥100 Hz) 和低 (≤20 Hz) 的刺激频率,以及更长的爆发持续时间 (2000-5000 ms),观察到脑内EEG峰值跨,β,和睡眠螺旋频率.
结论:
- 使用高频或低频的皮质体回应神经刺激,可以成为药物耐药焦点的有效辅助疗法.
- 这项研究有助于在焦点管理的背景下更好地了解胸膜电生理学.
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