相关实验视频

Updated: Jul 6, 2025

Predictive Immune Modeling of Solid Tumors

Predictive Immune Modeling of Solid Tumors

Published on: February 25, 2020

通过识别与亡相关的 lncRNAs 来预测瘤的预后和免疫状态

Zhen Wang¹, Anfang He¹, Zhengyu Lu¹

¹Department of Pathology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, Guangdong, China.

|January 9, 2024

概括

这项研究开发了一个预后风险模型,使用与亡相关的lncRNAs (NRlncRNAs) 用于肉瘤患者. 该模型有助于评估瘤预后和免疫状态,NRlncRNA SNHG6显示出重要的调节作用.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
生物信息学是一种生物信息学.

背景情况:

瘤是异质的恶性瘤,与亡有关.
尸亡在瘤瘤发生和进展中发挥着作用.

研究的目的:

评估与死相关的 lncRNAs (NRlncRNAs) 在肉瘤中的预后价值.
开发一个风险模型来评估肉瘤预后和免疫状态.

主要方法:

使用基因共同表达网络选NRlncRNAs.
开发并验证了对瘤的预后风险模型.
通过各种测试,研究了NRlncRNA SNHG6在骨髓瘤细胞中的功能.

主要成果:

基于5个NRlncRNAs的预后风险模型被开发出来,其中SNHG6是最重要的.
风险组之间观察到预后,临床特征和免疫状况的显著差异.
通过SNHG6的淘汰,抑制了骨髓瘤细胞的增殖,迁移和侵入,调节了AXL和AKT信号传递.

结论:

该NRlncRNA风险模型为肉瘤诊断,治疗和预后提供了一个新的参考.
NRlncRNA SNHG6调节了AXL和AKT信号,影响骨髓瘤细胞的行为.

关键词:

在SNHG6中,SNHG6是SNHG6.在此之前,TME的尸体亡 (necroptosis) 是一种致死症.风险模型的风险模型.这种类型的瘤是sarcomas.

更多相关视频

Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos

Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos

Published on: December 13, 2018

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

Published on: November 19, 2019

相关概念视频

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...