对柴油发动机排放和肺癌风险的职业暴露之间的剂量反应关系:系统性审查和元分析
Karla Romero Starke1, Ulrich Bolm-Audorff1, David Reissig1
1Institute and Policlinic of Occupational and Social Medicine, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
International journal of hygiene and environmental health
|January 9, 2024
概括
柴油发动机排放量 (DEE) 与肺癌风险增加有关. 一项系统性审查证实了积极的剂量反应关系,这表明当前的工作场所暴露限值可能需要重新评估.
科学领域:
- 职业健康 职业健康 职业健康
- 环境流行病学环境流行病学
- 毒理学 毒理学 毒理学
背景情况:
- 国际癌症研究机构在2012年将柴油发动机排放量 (DEE) 分类为致癌物.
- 由于有争议的剂量反应证据,关于DEE的致癌性仍存在争议.
结论:
- 确定了职业DEE暴露和肺癌风险之间的线性正剂量反应关系,特别是在高质量的暴露研究中.
- 这些发现挑战了现有的证据基础,并表明需要重新考虑现有的DEE工作场所值限制值.
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