从医院出院2年后的COVID-19:一个肺功能和胸部计算机断层扫描随访研究
Simone Mennella1, Cristiano Alicino2, Marco Anselmo3
1S.C. Radiologia P.O. Levante, ASL2 Savonese, Savona, Italy.
Respiration; international review of thoracic diseases
|January 9, 2024
概括
在严重的COVID-19发生两年后,许多患者经历了长期的COVID呼吸系统问题. 肺功能测试显示,在大量幸存者中,持续的肺损伤,包括肺容量和扩散的减少.
科学领域:
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
- 放射学 放射学是一门学科.
背景情况:
- 在严重的COVID-19后,建议进行肺功能测试 (PFT) 和胸部计算机断层扫描 (CT) 的连续随访.
- 有许多纵向研究,可进行长达1年的随访.
- 长期的呼吸系统后果需要进一步调查.
研究的目的:
- 进行一项为期2年的观察性研究,研究严重COVID-19幸存者的长期呼吸结果.
- 评估持续的呼吸损伤及其与临床和放射学发现的关联.
主要方法:
- 重症COVID-19患者在医院出院后 (2020年3月至6月) 被招募.
- 未来24个月的随访包括mMRC呼吸障碍量表和6,12和24个月的PFT.
- 胸部CT是根据临床指示进行的.
主要成果:
- 101名患者完成了24个月的随访.
- 在24个月后,16%的患者的肺总容量 (TLC) 减少,与75%的患者的纤维化磨砂玻璃不透明度 (GGO) 和69%的患者的mMRC得分>1相关.
- 41%的人的CO扩散能力降低,与53%的纤维化GGO相关,mMRC得分>1在22%.
结论:
- 许多严重的COVID-19幸存者经历了长期的呼吸损伤,表明"长期COVID".
- 持续的肺部异常,特别是纤维化GGO,与肺功能减弱和呼吸障碍有关.
- 这些发现凸显了在严重的COVID-19患者中扩大呼吸系统健康监测的需要.
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