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SARS-CoV-2 BA.2.86 进入肺细胞并高效避开中和抗体

Lu Zhang¹, Amy Kempf¹, Inga Nehlmeier²

¹Infection Biology Unit, German Primate Center, 37077 Göttingen, Germany; Faculty of Biology and Psychology, Georg-August-University Göttingen, 37073 Göttingen, Germany.

|January 9, 2024

概括

新型严重急性呼吸综合征冠状病毒2 (SARS-CoV-2) 变种BA.2.86有效地进入肺细胞并逃避抗体. 然而,它的低传染性可能会限制传播.

科学领域:

病毒学
免疫学
分子生物学

背景情况:

严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 持续演变,出现新的变种.
BA.2.86亚系是Omicron BA.2的后代,具有众多的尖端蛋白突变,并在全球范围内被检测到.
了解新出现的SARS-CoV-2变种的生物特征对于公共健康至关重要.

研究的目的:

调查SARS-CoV-2 BA.2.86变种的生物特征,重点关注病毒进入机制.
评估BA.2.86对治疗抗体和疫苗诱导免疫的敏感性.

主要方法:

使用伪型颗粒来评估病毒进入Calu-3肺细胞.
确实发现了真实的BA.2.86病毒.
通过非适应和XBB.1.5适应疫苗的抗体以及治疗性抗体进行中和.

主要成果:

BA.2.86 已证明有效地进入肺细胞,依赖于血清蛋白酶,但不依赖于囊蛋白酶.
真正的BA.2.86显示出强大的肺细胞感染,但具有较低的特定感染力.
BA.2.86对治疗抗体和非适应疫苗的抗体具有高耐药性.
来自XBB.1.5适应疫苗的抗体有效中和了BA.2.86和EG.5.1.

结论:

BA.2.86已经恢复了有效的肺细胞进入,这是早期SARS-CoV-2血统的特征.
这种变种对现有的基于抗体的干预措施具有显著的免疫逃避能力.
尽管BA.2.86具有其他关键特征,但其低的特定感染性可能会减轻其传染性.

关键词:

BA.2.86 其他冠状病毒尖子蛋白质其他:抗体逃离核聚变传染性进入肺细胞突变皮罗拉变种

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