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在小鼠中,DMH^Ppp1r17神经元通过下丘脑-脂肪系组织间的通信来调节老化和寿命

Kyohei Tokizane¹, Cynthia S Brace¹, Shin-Ichiro Imai²

¹Departments of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Cell metabolism

|January 9, 2024

概括

科学家们在下丘脑中发现了一种特定的神经元类型,该神经元控制老化和老鼠的寿命. 激活这些神经元可以改善健康和延长寿命,突出显示组织间的沟通.

科学领域:

神经科学是一个神经科学.
老年学是一门学科.
代谢过程中的代谢.

背景情况:

下丘脑是哺乳动物衰老和生理衰退的关键调节器.
组织间沟通对于抵消与年龄相关的衰退至关重要.

研究的目的:

为了确定在下丘脑中调节衰老和寿命的特定神经元群体.
为了研究Ppp1r17表达神经元在背中介质下丘脑 (DMH) 在衰老中的作用.
探索将下丘脑功能与衰老和白脂肪组织 (WAT) 健康联系起来的分子机制.

主要方法:

识别DMH Ppp1r17神经元及其在调节身体活动和WAT功能中的作用.
对cGMP依赖的蛋白激酶G (PKG;Prkg1) 途径和DMH神经元内的Ppp1r17转位的研究.
使用DMH特异性Prkg1敲除和化学遗传激活小鼠中的DMH Ppp1r17神经元.
评估对WAT功能,体力活动和寿命的影响.

主要成果:

DMH Ppp1r17神经元通过交感神经刺激和eNAMPT分泌来调节身体活动和WAT功能.
在DMH神经元内PKG介导的Ppp1r17酸化和转移会影响突触功能和WAT健康.
特定于DMH的Prkg1淘汰和DMH Ppp1r17神经元激活改善了与年龄相关的WAT功能障碍,增加了身体活动,并延长了寿命.

结论:

特定的DMH Ppp1r17神经元是老化和老鼠寿命的关键调节者.
由这些神经元介导的下丘脑和WAT之间的组织间通信对于控制衰老至关重要.
针对DMH神经元中的PKG-Ppp1r17通路提供了一种促进健康衰老的潜在策略.

关键词:

在DMH中,DMH是DMH.这是PKG PKG.在PPP1R17中老化的老化衰老的老化在背中介质下丘脑中.在 eNAMPT 中使用.长寿长寿是一个问题.蛋白质激酶 G 的蛋白质激酶 G.同情神经系统的同情神经系统.这是白色脂肪组织.

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