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抑郁症患者用电疗法治疗后认知副作用的治疗前预测因素:一个多中心研究

Dore Loef¹, Philip van Eijndhoven², Eva van den Munckhof²

¹Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Boelelaan 1117, Amsterdam, the Netherlands; Amsterdam Neuroscience, Mood, Anxiety, Psychosis, Sleep & Stress Program, Amsterdam, the Netherlands; GGZ inGeest Mental Health Care, Amsterdam, the Netherlands.

Journal of affective disorders

|January 9, 2024

概括

电疗法 (ECT) 暂时影响语言流性和记忆力. 年轻患者可能会出现更多的副作用,但随着时间的推移,认知功能会得到改善,甚至超过了基线水平.

科学领域:

神经科学是一个神经科学.
精神病学是一个精神病学.
认知心理学认知心理学

背景情况:

电疗法 (ECT) 是对重度抑郁症发作 (MDE) 的高效治疗方法.
对于患者来说,ECT后的认知副作用是一个很大的问题.
对于ECT诱导的认知衰退的预测因素尚不清楚.

研究的目的:

检查ECT后的认知表现随着时间的推移 (长达六个月).
在ECT后立即确定认知衰退的治疗前预测因素.

主要方法:

从2001年至2020年期间收集的数据分析了634名MDE患者的队列.
线性混合模型使用综合神经心理测试电池评估了随时间的认知变化.
线性回归确定了急性认知副作用的治疗前预测因素.

主要成果:

在ECT后立即观察到口语流和口语回忆的下降.
认知表现在三到六个月内显著改善,超过了基线水平.
年龄较小是治疗前与更大立即认知衰退相关的唯一预测因素.

结论:

电感疗法严重影响语言流性和记忆力,有暂时的认知副作用.
年轻的患者可能更容易受到急性认知副作用的影响,这是由于基线认知水平更高.
结果可以为治疗决策,患者教育和ECT管理策略提供信息.

关键词:

年龄年龄年龄年龄年龄年龄认知方面的副作用抑郁症抑郁症抑郁症电疗法是一种电疗法.预测者预测者

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Electroconvulsive Therapy

Electroconvulsive Therapy

Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...