免疫疗法和放射治疗对乳腺癌的测序:系统性审查
Saurav Verma1, Sympascho Young2, Gabriel Boldt3
1Division of Medical Oncology, Department of Oncology, Schulich School of Medicine & Dentistry, Western University, London, Ontario, Canada; London Regional Cancer Program at London Health Sciences Centre, London, Ontario, Canada.
International journal of radiation oncology, biology, physics
|January 9, 2024
概括
关于将免疫检查点抑制剂 (ICI) 与乳腺癌 (BC) 的放射治疗 (RT) 结合在一起的数据有限. 未来的试验需要报告RT细节,以便在BC治疗中获得最佳的测序和安全性.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 辐射瘤学 辐射瘤学
背景情况:
- 免疫检查点抑制剂 (ICI) 越来越多地用于乳腺癌 (BC).
- 同时放射治疗 (RT) 和ICI正在出现,特别是在外科手术前和转移后的环境中.
- 由于RT能够调节瘤微环境并诱导腹膜效应,因此支持将其与ICI结合使用.
研究的目的:
- 系统地审查在BC患者中结合ICI和RT的文献.
- 描述报告的治疗细节,ICI-RT组合的安全性和有效性.
- 确定与BC的ICI一起使用时,关于最佳RT参数的知识差距.
主要方法:
- 对2014年至2023年间发表的研究进行系统审查.
- 在PubMed,Embase和Cochrane CENTRAL数据库中进行的搜索.
- 数据提取的重点是ICI/RT交付,安全性和疗效结果.
主要成果:
- 确定了12项符合条件的研究,其中9项专注于转移性BC.
- 大多数研究都是小型的,异质的1/2期试验.
- 总体而言,ICI和RT的组合被报告为安全,对特定RT参数的数据有限.
结论:
- 有一个显著的数据缺乏最佳的RT剂量,时间,分成部分和体积,当与ICI结合在BC.
- 未来的临床试验必须在同时接受ICI的患者中仔细记录和报告RT细节.
- 对RT参数的标准化报告对于优化乳腺癌治疗中的ICI-RT策略至关重要.
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