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使用固体热解盐来促进微波诱导的现场无形化

Wei Qiang¹, Meng Zhang², Korbinian Löbmann³

¹School of Pharmacy, Queen's University Belfast, Belfast BT9 7BL, UK; Life Quality Engineering Interest Group, School of Chemical and Environmental Engineering, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China.

International journal of pharmaceutics

|January 9, 2024

概括

固体热解盐,如二碳酸 (NH4HCO3),为微波诱导的药物无形化提供了无水的替代品,防止水解. 这种方法提高了药物的稳定性和溶解性,优于传统的基于水分的系统.

科学领域:

制药技术制药技术制药技术
材料科学材料科学材料科学
化学工程是化学工程的重要组成部分.

背景情况:

微波诱导的现场无形化通常使用水分作为介电加热源.
基于水分的系统有毒药物水解的风险,限制了它们的应用.
需要新的方法来提高无形药物配方的稳定性和有效性.

研究的目的:

研究固体热解盐作为微波诱导的in situ无形化的水分替代品.
评估这些盐对酸性印梅他辛 (IND) 的无形化和盐形成的影响.
为了比较基于盐的系统与传统的基于水分的系统的性能.

主要方法:

使用氨二碳酸盐 (NH4HCO3) 作为固体热解盐.
研究了微波诱导的印莫他辛 (IND) 现场无形化和盐形成.
分析了微波时间,药物负载和聚合物比率对过程的影响.

主要成果:

NH4HCO3有效地促进了微波诱导的IND的in situ无形化和in situ盐形成.
该NH4HCO3系统减少了IND水解的可能性,并改善了溶解.
无形化先于盐形成,随后的盐形成受到NH3气体生成的影响.

结论:

固体热解盐,特别是NH4HCO3,是微波诱导无形化的可行的水分替代品.
NH4HCO3提高了IND紧材料的化学稳定性和溶解性能.
这种方法比基于水分的系统具有优势,包括降低水解风险和更广泛的聚合物适用性.

关键词:

无形固体的分散性固体.在现场无形化.微波炉微波炉微波炉微波炉微波炉微波炉微波炉微波炉微波炉微波炉微波聚合物的聚合物.盐盐盐盐盐盐盐

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