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基于分子印制聚合物开发和评估普洛素局部受控释放材料

Vanessa Galván-Romero¹, Fernando Gonzalez-Salazar¹, Karla Vargas-Berrones²

¹Centro de Investigación Aplicada en Ambiente y Salud (CIAAS), Universidad Autónoma de San Luis Potosí, Avenida Sierra Leona No. 550, Colonia Lomas Segunda Sección CP 78210, San Luis Potosí, SLP, Mexico.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

|January 9, 2024

概括

分子印记聚合物 (MIP) 显示出作为控制药物输送系统的潜力. 这些MIP显示出有效的抗菌活性,没有细胞毒性,有利于细胞生长.

科学领域:

聚合物化学聚合物化学
材料科学材料科学材料科学
生物医学工程生物医学工程

背景情况:

控制的药物输送系统对于有效的治疗结果至关重要.
普洛克萨是一种广泛使用的抗生素,需要优化输送方法.
分子印记聚合物 (MIP) 提供量身定制的分子识别能力.

研究的目的:

为了评估分子印记聚合物 (MIPs) 作为一种控制释放的系统,siprofloxacin.
用不同的方法和功能单体合成和描述MIP.
为了评估MIPs的抗菌疗效和细胞毒性,以潜在的临床应用.

主要方法:

通过乳液,散装和共同沉方法合成MIP和非印制聚合物 (NIP).
使用扫描电子显微镜,FTIR,特定表面积和孔径大小分析进行表征.
在皮肤纤维细胞中评估释放动力学,对黄金葡萄球菌和大肠杆菌的抗菌活性,以及皮肤纤维细胞中细胞毒性.

主要成果:

MIPs的特征是具有孔径大小从10到20纳米的中孔材料.
同沉合成产生了具有更高吸附能力的MIP,特别是以甲基酸 (MA) 为单体.
观察到非Fickian释放动力学,使用乳酸 (LA) 的共同降水MIP显示出最高的释放率 (90.51 mg/L在8小时内).
确定了两种细菌菌株的有效最小抑制度,没有观察到细胞毒性,细胞生长增强.

结论:

MIPs对受控的西普罗夫洛克萨输送表现出有希望的特征.
共同沉方法,特别是与LA或MA单体,对于MIP合成是有效的.
最低产品价值显示出药物管理和临床实践进步的巨大潜力.

关键词:

齐普罗夫洛克萨辛的使用方法有控制的交付方式.最低抑制度的最小抑制度有分子印记的聚合物.

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