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使用负载知情动力评估 (LIKE) 协议在椎间盘中进行日常活动的生理,体外模拟

D Lazaro-Pacheco¹, I Ebisch¹, T P Holsgrove¹

¹Department of Engineering, Faculty of Environment, Science and Economy, University of Exeter, Exeter, UK.

Journal of biomechanics

|January 9, 2024

概括

新的负载知情动力学评估 (LIKE) 协议准确地复制了体内脊柱负载条件. 这一进展对于理解椎间盘 (IVD) 机械生物学和评估新疗法至关重要.

科学领域:

生物力学生物力学
脊柱力学脊柱力学脊柱力学
椎间盘研究椎间盘研究

背景情况:

目前的脊柱测试使用简化的负载,不反映日常的多轴活动.
多轴负荷显著影响椎间盘 (IVD) 细胞活力.
将体内负载数据集成到脊柱模拟器中至关重要,但面临诸如负载合和变速率等挑战.

研究的目的:

引入和验证负载知情运动评估 (LIKE) 协议,用于复制生理脊柱负荷.
为了克服模拟复杂的挑战,在脊柱上模拟多轴负荷条件.
为了能够更准确地进行IVD设备和治疗的临床前评估.

主要方法:

该Like协议包括三个阶段:动力学获取,多轴负载应用和长期测试与日间高度校正.
第1阶段使用了六轴负载控制测试来捕获20个 Orthoload 活动的动力学在减速时.
阶段2和3应用了这些动力学与轴向压缩,降低和生理速率,并纳入了日间高度校正的长期稳定性.

主要成果:

第1阶段实现了根平均平方误差 (RMSEs) 在负载单元噪声底线的两倍范围内.
第二阶段在所有轴的降低和生理测试速率均显示出低RMSEs.
第三阶段使得生理活动的稳定,长期复制成为可能,可控的轴和剪切RMSEs.

结论:

该Like协议成功地复制了复杂的生理脊柱负荷条件.
该协议增强了对椎间盘 (IVD) 机械生物学的研究.
LIKE为IVD疗法和设备的临床前评估提供了一个强大的平台.

关键词:

生物反应器是一种生物反应器.椎间盘之间的椎间盘.生理负荷物理负荷有六个轴的六轴.脊柱生物力学脊柱生物力学

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