在功能和日常活动中复制脊柱负荷:一个体内,体内,体外研究管道
I Ebisch1, D Lazaro-Pacheco1, D J Farris2
1Department of Engineering, Faculty of Environment, Science and Economy, University of Exeter, Exeter, UK.
Journal of biomechanics
|January 9, 2024
概括
这项研究开发了一种非侵入性方法,以估计脊椎间盘 (IVD) 的负载在体内,并将其应用在体外. 这种方法通过模拟现实世界的负载条件来改善脊柱生物力学研究和临床前测试.
科学领域:
- 生物力学 生物力学
- 脊柱研究 脊柱研究
- 医疗器械技术 医疗器械技术
背景情况:
- 椎间盘 (IVD) 负荷受生活方式的影响,但体内测量是侵入性的.
- 现有的体内负载数据仅限于术后患者,影响了概括性.
- 目前用于应用IVD负荷的体外试验方法受到限制.
研究的目的:
- 开发一个管道,用于在体内IVD负载的非侵入性估计.
- 为了更准确的测试,在体外应用这些估计的生理负荷.
- 为了比较体外动力学在生理负荷下与传统纯时刻协议相比.
主要方法:
- 通过结合现有模型创建了一个全身的Opensim模型.
- 利用健康个体在日常活动中的动力数据进行静态优化模拟.
- 将估计的六轴生理负荷应用于牛尾样本进行体外试验.
主要成果:
- 开发的管道成功估计了体内脊椎间盘负载.
- 用生理负荷进行的体外试验显示出与in silico和in vivo数据一致的动力学趋势.
- 与纯矩测试相比,生理负载应用导致了明显不同的动力学,特别是在曲过程中.
结论:
- 该管道为估计不同人群中复杂的日常活动负载提供了新的能力.
- 在实验室中应用这些估计的生理负载可以增强临床前测试方法.
- 这种方法加深了对脊柱生物力学和椎间盘机械生物学的理解.
相关概念视频
Cable Subjected to a Distributed Load
The analysis of suspension bridges is a complex and critical process that involves multiple factors, including the shape and tension of the main cables. The main cables of suspension bridges are subjected to distributed loads, which result in changes in tensile forces and deformation of the cable. These loads must be carefully considered to ensure that the bridge is safe and capable of supporting the weight of different loads.
Cable Subjected to Its Own Weight
Overhead power transmission lines rely on cables to carry electricity across large distances. To ensure the stability and functionality of these lines, it is crucial to understand the shape and tension experienced by the cables under the influence of their weight.
A generalized loading function is employed to analyze a cable subjected to its own weight. This function considers the force acting along the cable's arc length rather than its projected length, providing a more accurate...
A generalized loading function is employed to analyze a cable subjected to its own weight. This function considers the force acting along the cable's arc length rather than its projected length, providing a more accurate...
Applications of Stress
Consider a structure made of a boom and a rod designed to support a load. These two components are connected by a pin and stabilized by brackets and pins. The boom and the rod are detached from their supports to assess the different stresses imposed on this structure, and a free-body diagram is drawn. Then, all the forces applied, including the load acting on the structure, are identified. The reaction forces exerted on both the boom and the rod are computed using the equilibrium equations.
The...
The...
Stresses under Combined Loadings
When analyzing a bent tube with a circular cross-section subjected to multiple forces, it is crucial to determine the stress distribution in order to maintain structural integrity under varied load conditions.
The process begins by slicing the tube at critical points and analyzing the internal forces and stress components at these sections, focusing on the centroid. Normal stresses, generated by axial forces and bending moments, are either compressive or tensile and vary across the section from...
The process begins by slicing the tube at critical points and analyzing the internal forces and stress components at these sections, focusing on the centroid. Normal stresses, generated by axial forces and bending moments, are either compressive or tensile and vary across the section from...


